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The Lewis A phenotype is a restriction factor for Rotateq and Rotarix vaccine-take in Nicaraguan children
Natl Autonomous Univ Nicaragua, Nicaragua.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
Natl Autonomous Univ Nicaragua, Nicaragua.
Natl Autonomous Univ Nicaragua, Nicaragua.
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2018 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, article id 1502Article in journal (Refereed) Published
Abstract [en]

Histo-blood group antigens (HBGAs) and the Lewis and secretor antigens are associated with susceptibility to rotavirus infection in a genotype-dependent manner. Nicaraguan children were prospectively enrolled in two cohorts vaccinated with either RotaTeq RV5 (n = 68) or Rotarix RV1 (n = 168). Lewis and secretor antigens were determined by saliva phenotyping and genotyping. Seroconversion was defined as a 4-fold increase in plasma IgA antibody titer 1 month after administration of the first dose of the vaccine. Regardless of the vaccine administered, significantly fewer of the children with Lewis A phenotype (0/14) seroconverted after receiving the first vaccine dose compared to 26% (45/175) of those with the Lewis B phenotype and 32% (15/47) of the Lewis negative individuals (P amp;lt; 0.01). Furthermore, following administration of the RV1 vaccine, secretor-positive ABO blood group B children seroconverted to a significantly lesser extent (5%) compared to secretor-positive children with ABO blood groups A (26%) and O (27%) (P amp;lt; 0.05). Other factors such as pre-vaccination titers, sex, breastfeeding, and calprotectin levels did not influence vaccine-take. Differences in HBGA expression appear to be a contributing factor in the discrepancy in vaccine-take and thus, in vaccine efficacy in different ethnic populations.

Place, publisher, year, edition, pages
NATURE PUBLISHING GROUP , 2018. Vol. 8, article id 1502
National Category
Infectious Medicine
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URN: urn:nbn:se:liu:diva-145130DOI: 10.1038/s41598-018-19718-yISI: 000423154000032PubMedID: 29367698OAI: oai:DiVA.org:liu-145130DiVA, id: diva2:1183659
Note

Funding Agencies|Swedish Research Council [348-2013-6587, 2011-3469-90642-57]

Available from: 2018-02-19 Created: 2018-02-19 Last updated: 2018-03-10

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Nordgren, JohanSharma, SumitSvensson, Lennart
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