liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
A cannabinoid receptor antagonist attenuates ghrelin-induced activation of the mesolimbic dopamine system in mice
Univ Gothenburg, Sweden.
Univ Gothenburg, Sweden.
Univ Gothenburg, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Center for Social and Affective Neuroscience. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Local Health Care Services in Central Östergötland, Department of Psychiatry.
Show others and affiliations
2018 (English)In: Physiology and Behavior, ISSN 0031-9384, E-ISSN 1873-507X, Vol. 184, p. 211-219Article in journal (Refereed) Published
Abstract [en]

Ghrelin has been attributed various physiological processes including food intake and reward regulation, through activation of the mesolimbic dopamine system. Reward modulation involves the mesolimbic dopamine system, consisting of the ventral tegmental area (VTA) dopamine neurons targeting nucleus accumbens (NAc), a system that ghrelin activates through VTA-dependent mechanisms. In the first study, we found that systemic intraperitoneal (ip) administration of rimonabant attenuated intracerebroventricular (icv) ghrelins ability to cause locomotor stimulation and NAc dopamine release in mice. Ghrelin-induced (icv) chow intake was not altered by rimonabant administration (ip). Finally, we showed that bilateral VTA administration of rimonabant blocks the ability of intra-VTA administered ghrelin to increase locomotor activity, but does not affect food intake in mice. Collectively, these data indicate clear dissociation between regulation of food intake and activation of the mesolimbic dopamine system.

Place, publisher, year, edition, pages
PERGAMON-ELSEVIER SCIENCE LTD , 2018. Vol. 184, p. 211-219
Keywords [en]
Ghrelin; Endocannabinoids; Cannabinoid receptors type 1; Mesolimbic dopamine system; Food intake
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:liu:diva-145118DOI: 10.1016/j.physbeh.2017.12.005ISI: 000423637200028PubMedID: 29221808OAI: oai:DiVA.org:liu-145118DiVA, id: diva2:1183676
Note

Funding Agencies|Swedish Research Council [2015-03219]; Swedish Society for Medical Research; Swedish Brain Foundation; LUA/ALF from the Sahlgrenska University Hospital [148251]; Torsten Soderberg; Alcohol research council of the Swedish alcohol retailing monopoly; foundation of Adlerbertska; foundation of Fredrik and Ingrid Thuring; foundation of Tore Nilsson; foundation of Langmanska; foundation of Wilhelm and Martina Lundgren; foundation of Knut and Alice Wallenberg; foundation of Magnus Bergvall; foundation of Aners; foundation of Jeansons; foundation of Ake Wiberg; foundation of NovoNordisk; Swedish Society of Medicine

Available from: 2018-02-19 Created: 2018-02-19 Last updated: 2018-02-19

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Heilig, Markus
By organisation
Center for Social and Affective NeuroscienceFaculty of Medicine and Health SciencesDepartment of Psychiatry
In the same journal
Physiology and Behavior
Neurosciences

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 4178 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf