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Stereotactic Brain Tumor Optical Biopsy
Linköping University, Department of Biomedical Engineering, Division of Biomedical Engineering. Linköping University, Faculty of Science & Engineering. (MINT)ORCID iD: 0000-0002-0555-8877
Linköping University, Department of Biomedical Engineering. Linköping University, Faculty of Science & Engineering. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Neurosurgery.
Linköping University, Department of Clinical and Experimental Medicine, Divison of Neurobiology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Clinical pathology.ORCID iD: 0000-0001-6716-0314
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Neurosurgery. (MINT)
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2018 (English)Conference paper, Oral presentation with published abstract (Other academic)
Abstract [en]

To provide guidance for targeting diagnostic tumor tissue and to avoid vessel rupture during the biopsy procedure an application specific fiber optic probe was devel-oped. The setup incorporated an in-house developed fluorescence spectroscopy system for 5-aminolevulinic acid (5-ALA) induced protopophyrin IX (PpIX) for detection in the tumor, and laser Doppler flowmeter (LDF) system for measurement of blood perfusion. Fluorescence and blood flow were recorded millimeter-wise towards the pre-calculated target. In conclusion, the optical probe made real-time detection of tumor possible and has a potential for vessel detection during the biopsy procedures. Moreover, the PpIX fluorescence, autofluorescence and blood flow in the tumor could be studied at precise positions in the brain and the tumor. In the next step, further anal-ysis will be added.

Place, publisher, year, edition, pages
Prague, 2018.
National Category
Other Medical Engineering
Identifiers
URN: urn:nbn:se:liu:diva-145220OAI: oai:DiVA.org:liu-145220DiVA, id: diva2:1183692
Conference
World Conference on Medical Physics and Biomedical Engineering (IUPESM,Prague, Czeck Republic, June 3-8 2018
Funder
Swedish Childhood Cancer Foundation, MT 2013-0043Available from: 2018-02-19 Created: 2018-02-19 Last updated: 2019-10-14Bibliographically approved

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Haj-Hosseini, NedaHallbeck, MartinMilos, PeterWårdell, Karin

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Haj-Hosseini, NedaRichter, JohanHallbeck, MartinMilos, PeterWårdell, Karin
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Division of Biomedical EngineeringFaculty of Science & EngineeringDepartment of Biomedical EngineeringDepartment of NeurosurgeryDivison of NeurobiologyFaculty of Medicine and Health SciencesClinical pathologyDivision of Neuro and Inflammation Science
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