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Stereotactic Brain Tumor Optical Biopsy
Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. (MINT)ORCID iD: 0000-0002-0555-8877
Östergötlands Läns Landsting, Reconstruction Centre, Department of Neurosurgery UHL. Linköping University, Department of Biomedical Engineering.
Östergötlands Läns Landsting, Center for Diagnostics, Department of Clinical Pathology and Clinical Genetics. Linköping University, Department of Clinical and Experimental Medicine, Experimental Pathology.
Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Neurosurgery. Neurokirurgi. (MINT)
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2018 (English)Conference paper, Oral presentation with published abstract (Refereed)
Abstract [en]

To provide guidance for targeting diagnostic tumor tissue and to avoid vessel rupture during the biopsy procedure an application specific fiber optic probe was devel-oped. The setup incorporated an in-house developed fluorescence spectroscopy system for 5-aminolevulinic acid (5-ALA) induced protopophyrin IX (PpIX) for detection in the tumor, and laser Doppler flowmeter (LDF) system for measurement of blood perfusion. Fluorescence and blood flow were recorded millimeter-wise towards the pre-calculated target. In conclusion, the optical probe made real-time detection of tumor possible and has a potential for vessel detection during the biopsy procedures. Moreover, the PpIX fluorescence, autofluorescence and blood flow in the tumor could be studied at precise positions in the brain and the tumor. In the next step, further anal-ysis will be added.

Place, publisher, year, edition, pages
Prague, 2018.
National Category
Other Medical Engineering
Identifiers
URN: urn:nbn:se:liu:diva-145220OAI: oai:DiVA.org:liu-145220DiVA, id: diva2:1183692
Conference
World Conference on Medical Physics and Biomedical Engineering (IUPESM)
Funder
Swedish Childhood Cancer Foundation, MT 2013-0043Available from: 2018-02-19 Created: 2018-02-19 Last updated: 2018-02-19

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Haj-Hosseini, NedaRichter, JohanHallbeck, MartinMilos, PeterWårdell, Karin
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The Institute of TechnologyBiomedical InstrumentationDepartment of Neurosurgery UHLDepartment of Biomedical EngineeringDepartment of Clinical Pathology and Clinical GeneticsExperimental PathologyDepartment of Neurosurgery
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CiteExportLink to record
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