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Acute effects of coffee on skin blood flow and microvascular function
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Radiation Physics.ORCID iD: 0000-0002-8387-0583
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Clinical Chemistry.
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery.
2017 (English)In: Microvascular Research, ISSN 0026-2862, E-ISSN 1095-9319, Vol. 114, p. 58-64Article in journal (Refereed) Published
Abstract [en]

Objective

Studies on the acute effects of coffee on the microcirculation have shown contradicting results. This study aimed to investigate if intake of caffeine-containing coffee changes blood flow and microvascular reactivity in the skin.

Methods

We measured acute changes in cutaneous vascular conductance (CVC) in the forearm and the tip of the finger, the microvascular response to transdermaliontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP) and post-occlusive reactive hyperemia (PORH) in the skin, after intake of caffeinated or decaffeinated coffee.

Results

Vasodilatation during iontophoresis of ACh was significantly stronger after intake of caffeinated coffee compared to after intake of decaffeinated coffee (1.26 ± 0.20 PU/mm Hg vs. 1.13 ± 0.38 PU/mm Hg, P < 0.001). Forearm CVC before and after PORH were not affected by caffeinated and decaffeinated coffee. After intake of caffeinated coffee, a more pronounced decrease in CVC in the fingertip was observed compared to after intake of decaffeinated coffee (− 1.36 PU/mm Hg vs. − 0.52 PU/mm Hg, P = 0.002).

Conclusions

Caffeine, as ingested by drinking caffeinated coffee acutely improves endothelium-dependent microvascular responses in the forearm skin, while endothelium-independent responses to PORH and SNP iontophoresis are not affected. Blood flow in the fingertip decreases markedly during the first hour after drinking caffeinated coffee compared to decaffeinated coffee.

Place, publisher, year, edition, pages
Academic Press, 2017. Vol. 114, p. 58-64
Keywords [en]
Coffee, Caffeine, Skin, Microcirculation, Laser Doppler flowmetry, Laser speckle contrast imaging
National Category
Anesthesiology and Intensive Care
Identifiers
URN: urn:nbn:se:liu:diva-145382DOI: 10.1016/j.mvr.2017.06.006ISI: 000431155100009PubMedID: 28625890Scopus ID: 2-s2.0-85020924088OAI: oai:DiVA.org:liu-145382DiVA, id: diva2:1186169
Available from: 2018-02-27 Created: 2018-02-27 Last updated: 2019-01-11Bibliographically approved

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Tesselaar, ErikNezirevic Dernroth, DzenetaFarnebo, Simon

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Division of Surgery, Orthopedics and OncologyFaculty of Medicine and Health SciencesDivision of Radiological SciencesDepartment of Radiation PhysicsDivision of Microbiology and Molecular MedicineDepartment of Clinical ChemistryDepartment of Hand and Plastic Surgery
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