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Pax6-dependent, but β-catenin-independent, function of Bcl9 proteins in mouse lens development.
Institute of Molecular Life Sciences, University of Zurich, 8057 Zurich, Switzerland.
Institute of Molecular Life Sciences, University of Zurich, 8057 Zurich, Switzerland.
Institute of Molecular Life Sciences, University of Zurich, 8057 Zurich, Switzerland.
Institute of Molecular Life Sciences, University of Zurich, 8057 Zurich, Switzerland.
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2014 (English)In: Genes & Development, ISSN 0890-9369, E-ISSN 1549-5477, Vol. 28, no 17, p. 1879-84Article in journal (Refereed) Published
Abstract [en]

Bcl9 and Bcl9l (Bcl9/9l) encode Wnt signaling components that mediate the interaction between β-catenin and Pygopus (Pygo) via two evolutionarily conserved domains, HD1 and HD2, respectively. We generated mouse strains lacking these domains to probe the β-catenin-dependent and β-catenin-independent roles of Bcl9/9l and Pygo during mouse development. While lens development is critically dependent on the presence of the HD1 domain, it is not affected by the lack of the HD2 domain, indicating that Bcl9/9l act in this context in a β-catenin-independent manner. Furthermore, we uncover a new regulatory circuit in which Pax6, the master regulator of eye development, directly activates Bcl9/9l transcription.

Place, publisher, year, edition, pages
2014. Vol. 28, no 17, p. 1879-84
Keywords [en]
Bcl9, Pax6, Pygopus, Wnt, lens induction, mouse
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-145417DOI: 10.1101/gad.246140.114PubMedID: 25184676OAI: oai:DiVA.org:liu-145417DiVA, id: diva2:1187022
Available from: 2018-03-02 Created: 2018-03-02 Last updated: 2018-03-09

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CiteExportLink to record
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Citation style
  • apa
  • ieee
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  • oxford
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  • de-DE
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Output format
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