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TNF signaling: early events and phosphorylation.
Institute of Virology, Slovak Academy of Sciences, Dúbravská cesta 9, 842 45 Bratislava, Slovakia.ORCID iD: 0000-0001-5751-3622
Institute of Virology, Slovak Academy of Sciences, Dúbravská cesta 9, 842 45 Bratislava, Slovakia.
2007 (English)In: General Physiology and Biophysics, ISSN 0231-5882, E-ISSN 1338-4325, Vol. 26, no 3, p. 159-67Article in journal (Refereed) Published
Abstract [en]

Tumor necrosis factor-alpha (TNF) is a major mediator of apoptosis as well as immunity and inflammation. Inappropriate production of TNF or sustained activation of TNF signaling has been implicated in the pathogenesis of a wide spectrum of human diseases, including cancer, osteoporosis, sepsis, diabetes, and autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease. TNF binds to two specific receptors, TNF-receptor type I (TNF-R1, CD120a, p55/60) and TNF-receptor type II (TNF-R2, CD120b, p75/80). Signaling through TNF-R1 is extremely complex, leading to both cell death and survival signals. Many findings suggest an important role of phosphorylation of the TNF-R1 by number of protein kinases. Role of TNF-R2 phosphorylation on its signaling properties is understood less than TNF-R1. Other cellular substrates as TRADD adaptor protein, TRAF protein family and RIP kinases are reviewed in relation to TNF receptor-mediated apoptosis or survival pathways and regulation of their actions by phosphorylation.

Place, publisher, year, edition, pages
Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences , 2007. Vol. 26, no 3, p. 159-67
National Category
Cell and Molecular Biology Cell Biology Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) Biochemistry and Molecular Biology Immunology in the medical area
Identifiers
URN: urn:nbn:se:liu:diva-145517ISI: 000251272400001PubMedID: 18063842OAI: oai:DiVA.org:liu-145517DiVA, id: diva2:1187416
Available from: 2018-03-05 Created: 2018-03-05 Last updated: 2019-01-22Bibliographically approved

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Ihnatko, Robert

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Cell and Molecular BiologyCell BiologyMedical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)Biochemistry and Molecular BiologyImmunology in the medical area

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