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On-line soft sensing in upstream bioprocessing
Linköping University, Department of Physics, Chemistry and Biology, Biotechnology. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Physics, Chemistry and Biology, Biotechnology. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0001-9711-794X
2018 (English)In: Critical reviews in biotechnology, ISSN 0738-8551, E-ISSN 1549-7801, Vol. 38, no 1, p. 106-121Article, review/survey (Refereed) Published
Abstract [en]

This review provides an overview and a critical discussion of novel possibilities of applying soft sensors for on-line monitoring and control of industrial bioprocesses. Focus is on bio-product formation in the upstream process but also the integration with other parts of the process is addressed. The term soft sensor is used for the combination of analytical hardware data (from sensors, analytical devices, instruments and actuators) with mathematical models that create new real-time information about the process. In particular, the review assesses these possibilities from an industrial perspective, including sensor performance, information value and production economy. The capabilities of existing analytical on-line techniques are scrutinized in view of their usefulness in soft sensor setups and in relation to typical needs in bioprocessing in general. The review concludes with specific recommendations for further development of soft sensors for the monitoring and control of upstream bioprocessing.

Place, publisher, year, edition, pages
TAYLOR & FRANCIS LTD , 2018. Vol. 38, no 1, p. 106-121
Keywords [en]
Biomanufacturing; biotechnology; bioreactor monitoring; in situ measurement; real-time analysis
National Category
Dermatology and Venereal Diseases
Identifiers
URN: urn:nbn:se:liu:diva-145254DOI: 10.1080/07388551.2017.1312271ISI: 000423834000008PubMedID: 28423945OAI: oai:DiVA.org:liu-145254DiVA, id: diva2:1188332
Note

Funding Agencies|EU-Horizon Marie Sklodowska-Curie Innovative Training Network BIORAPID [643056]; Linkoping University

Available from: 2018-03-07 Created: 2018-03-07 Last updated: 2019-01-22

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CiteExportLink to record
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Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
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  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
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