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Air-Stable Gadolinium Precursors for the Facile Microwave-Assisted Synthesis of Gd2O3 Nanocontrast Agents for Magnetic Resonance Imaging
Univ Cologne, Germany.
Univ Cologne, Germany.
Univ Cologne, Germany.
Linköping University, Department of Physics, Chemistry and Biology, Molecular Surface Physics and Nano Science. Linköping University, Faculty of Science & Engineering.
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2018 (English)In: Crystal Growth & Design, ISSN 1528-7483, E-ISSN 1528-7505, Vol. 18, no 2, p. 633-641Article in journal (Refereed) Published
Abstract [en]

Using metal organic precursors in materials synthesis remains a challenge due to their high moisture susceptibility. In this work, we describe a facile methodology for the synthesis of Gd2O3-based contrast agents from two new gadolinium-based complexes. [Gd(PyTFP)(4)] (PyH) 1 (PyTFP = C8H5NOF3, Py = C5H5N) and [Gd(DMOTFP)(3)Py] 2 (DMOTFP = C8H7NO2F3) were synthesized via a classical ligand exchange reaction of [Gd{N(SiMe3)(2)}(3)] under inert conditions. As a result, X-ray diffraction analysis revealed a distorted square antiprismatic coordination and an augmented triangular prismatic arrangement of ligands around gadolinium atoms in 1 and 2, respectively. It also showed that 1 is an anionic complex of formula [Gd(PyTFP)(4)](PyH), while a neutral tris-compound, [Gd(DMOTFP)(3)Py], was obtained as a pyridine adduct in 2. Fast and reproducible microwave-assisted decomposition of 1 and 2 provided homogeneous Gd(OH)(3) nanorods at mild temperature without using any surfactant or capping reagent. As-synthesized nanorods were easily transformed into a cubic phase of Gd2O3 nanoparticles by thermal treatment under ambient conditions. The magnetic measurement showed the typical paramagnetic behavior of the Gd2O3 nanoparticles (NPs). The cytotoxicity profile demonstrates the biocompatibility and negligible toxicity of the as-synthesized nanoprobes. The suggested approach provides a new class of gadolinium-based precursors which allows facile synthesis of highly crystalline Gd2O3 NPs.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2018. Vol. 18, no 2, p. 633-641
National Category
Inorganic Chemistry
Identifiers
URN: urn:nbn:se:liu:diva-145458DOI: 10.1021/acs.cgd.7b00787ISI: 000424851400013Scopus ID: 2-s2.0-85041919085OAI: oai:DiVA.org:liu-145458DiVA, id: diva2:1192847
Note

Funding Agencies|University of Cologne; "Deutscher Akademischer Austauschdienst" (DAAD); Swedish Government Strategic Research Area in Materials Science on Functional Materials at Linkoping University [2009-00971]

Available from: 2018-03-23 Created: 2018-03-23 Last updated: 2018-03-29Bibliographically approved

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