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Copper oxide nanoparticles induce anticancer activity in A549 lung cancer cells by inhibition of histone deacetylase
Bharathidasan Univ, India.
Bharathidasan Univ, India; Ohio State Univ, OH 44691 USA.
Bharathidasan Univ, India.
Bharathidasan Univ, India.
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2018 (English)In: Biotechnology letters, ISSN 0141-5492, E-ISSN 1573-6776, Vol. 40, no 2, p. 249-256Article in journal (Refereed) Published
Abstract [en]

Copper oxide nanoparticles (CuO NPs) promoting anticancer activity may be due to the regulation of various classes of histone deacetylases (HDACs). Green-synthesized CuO NPs significantly arrested total HDAC level and also suppressed class I, II and IV HDACs mRNA expression in A549 cells. A549 cells treated with CuO NPs downregulated oncogenes and upregulated tumor suppressor protein expression. CuO NPs positively regulated both mitochondrial and death receptor-mediated apoptosis caspase cascade pathway in A549 cells. Green-synthesized CuO NPs inhibited HDAC and therefore shown apoptosis mediated anticancer activity in A549 lung cancer cell line.

Place, publisher, year, edition, pages
Springer Netherlands, 2018. Vol. 40, no 2, p. 249-256
Keywords [en]
Anticancer activity; Apoptosis; A549 cells; Copper oxide nanoparticles; Epigenetic; Histone deacetylase
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:liu:diva-145455DOI: 10.1007/s10529-017-2463-6ISI: 000425115100003PubMedID: 29116558Scopus ID: 2-s2.0-85033389854OAI: oai:DiVA.org:liu-145455DiVA, id: diva2:1192868
Note

Funding Agencies|Department of Educational Technology, Bharathidasan University, Tiruchirappalli

Available from: 2018-03-23 Created: 2018-03-23 Last updated: 2018-04-03Bibliographically approved

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Karthic, Selvaraj
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Division of Drug ResearchFaculty of Medicine and Health SciencesDepartment of Clinical Pharmacology
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