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Temperature-corrected postmortem 3-T MR quantification of histopathological early acute and chronic myocardial infarction: a feasibility study
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Radiology in Linköping. Linköping University, Center for Medical Image Science and Visualization (CMIV).ORCID iD: 0000-0002-9446-6981
Natl Board Forens Med Linkoping, Dept Forens Med, Linkoping, Sweden.
Natl Board Forens Med Linkoping, Dept Forens Med, Linkoping, Sweden.
Univ Bern, Switzerland.
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2018 (English)In: International journal of legal medicine (Print), ISSN 0937-9827, E-ISSN 1437-1596, Vol. 132, no 2, p. 541-549Article in journal (Refereed) Published
Abstract [en]

The goal of the present study was to evaluate if quantitative postmortem cardiac 3-T magnetic resonance (QPMCMR) T1 and T2 relaxation times and proton density values of histopathological early acute and chronic myocardial infarction differ to the quantitative values of non-pathologic myocardium and other histopathological age stages of myocardial infarction with regard to varying corpse temperatures. In 60 forensic corpses (25 female, 35 male), a cardiac 3-T MR quantification sequence was performed prior to autopsy and cardiac dissection. Core body temperature was assessed during MR examinations. Focal myocardial signal alterations in synthetically generated MR images were measured for their T1, T2, and proton density (PD) values. Locations of signal alteration measurements in PMCMR were targeted at heart dissection, and myocardial tissue specimens were taken for histologic examinations. Quantified signal alterations in QPMCMR were correlated to their according histologic age stage of myocardial infarction, and quantitative values were corrected for a temperature of 37 A degrees C. In QPMCMR, 49 myocardial signal alterations were detected in 43 of 60 investigated hearts. Signal alterations were diagnosed histologically as early acute (n = 16), acute (n = 10), acute with hemorrhagic component (n = 9), subacute (n = 3), and chronic (n = 11) myocardial infarction. Statistical analysis revealed that based on their temperature-corrected quantitative T1, T2, and PD values, a significant difference between early acute, acute, and chronic myocardial infarction can be determined. It can be concluded that quantitative 3-T postmortem cardiac MR based on temperature-corrected T1, T2, and PD values may be feasible for pre-autopsy diagnosis of histopathological early acute, acute, and chronic myocardial infarction, which needs to be confirmed histologically.

Place, publisher, year, edition, pages
SPRINGER , 2018. Vol. 132, no 2, p. 541-549
Keyword [en]
Postmortem MRI; Quantitative MRI; Myocardial infarction; Relaxation times; Proton density
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:liu:diva-145443DOI: 10.1007/s00414-017-1614-6ISI: 000424652900022PubMedID: 28612206OAI: oai:DiVA.org:liu-145443DiVA, id: diva2:1192907
Available from: 2018-03-23 Created: 2018-03-23 Last updated: 2018-03-23

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Persson, AndersWarntjes, Marcel Jan BertusZech, Wolf-Dieter
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Division of Radiological SciencesFaculty of Medicine and Health SciencesDepartment of Radiology in LinköpingCenter for Medical Image Science and Visualization (CMIV)Division of Cardiovascular MedicineDepartment of Clinical Physiology in Linköping
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International journal of legal medicine (Print)
Cardiac and Cardiovascular Systems

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