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Time-dependent biodistribution, clearance and biocompatibility of magnetic fibrin nanoparticles: an in vivo study.
Bio-Products Laboratory, Central Leather Research Institute (CLRI), Adyar, Chennai 600 020, India .
Bio-Products Laboratory, Central Leather Research Institute (CLRI), Adyar, Chennai 600 020, India .
Bio-Products Laboratory, Central Leather Research Institute (CLRI), Adyar, Chennai 600 020, India .
2015 (English)In: Nanoscale, ISSN 2040-3364, E-ISSN 2040-3372, Vol. 7, no 21, p. 9676-9685Article in journal (Refereed) Published
Abstract [en]

Recently, bioretention and toxicity of injected nanoparticles in the body has drawn much attention in biomedical research. In the present study, 5 mg Fe per kg body weight of magnetic fibrin nanoparticles (MFNPs) were injected into mice intravenously and investigated for their blood clearance profile, biodistribution, haematology and pathology studies for a time period of 28 days. Moderately long circulation of MFNPs in blood was observed with probable degradation and excretion into the bloodstream via monoatomic iron forms. Inductively coupled plasma optical emission spectrometry (ICP-OES) and Prussian blue staining results showed increased accumulation of MFNPs in the liver, followed by spleen and other organs. Body weight, spleen/thymus indexes, haematology, serum biochemistry and histopathology studies demonstrated that MFNPs were biocompatible. These results suggest the feasibility of using MFNPs for drug delivery and imaging applications.

Place, publisher, year, edition, pages
Royal Society of Chemistry, 2015. Vol. 7, no 21, p. 9676-9685
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:liu:diva-146240DOI: 10.1039/c5nr00113gPubMedID: 25959634OAI: oai:DiVA.org:liu-146240DiVA, id: diva2:1195083
Available from: 2018-04-04 Created: 2018-04-04 Last updated: 2018-04-23

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