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SyMRI of the Brain: Rapid Quantification of Relaxation Rates and Proton Density, With Synthetic MRI, Automatic Brain Segmentation, and Myelin Measurement
Department of Radiology, Juntendo University School of Medicine, Japan; Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan .
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV). Region Östergötland, Heart and Medicine Center, Department of Clinical Physiology in Linköping.
Department of Radiology, Juntendo University School of Medicine, Japan; Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan .
Department of Radiology, Juntendo University School of Medicine, Japan; Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan .
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2017 (English)In: Investigative Radiology, ISSN 0020-9996, E-ISSN 1536-0210, Vol. 52, no 10, p. 647-657Article, review/survey (Refereed) Published
Abstract [en]

Conventional magnetic resonance images are usually evaluated using the image signal contrast between tissues and not based on their absolute signal intensities. Quantification of tissue parameters, such as relaxation rates and proton density, would provide an absolute scale; however, these methods have mainly been performed in a research setting. The development of rapid quantification, with scan times in the order of 6 minutes for full head coverage, has provided the prerequisites for clinical use. The aim of this review article was to introduce a specific quantification method and synthesis of contrast-weighted images based on the acquired absolute values, and to present automatic segmentation of brain tissues and measurement of myelin based on the quantitative values, along with application of these techniques to various brain diseases. The entire technique is referred to as "SyMRI" in this review. SyMRI has shown promising results in previous studies when used for multiple sclerosis, brain metastases, Sturge-Weber syndrome, idiopathic normal pressure hydrocephalus, meningitis, and postmortem imaging.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2017. Vol. 52, no 10, p. 647-657
Keywords [en]
SyMRI, synthetic MRI, quantitative MRI, QRAPMASTER, brain, relaxation rates, proton density, automatic brain segmentation, myelin measurement, multiple sclerosis
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:liu:diva-146343DOI: 10.1097/RLI.0000000000000365ISI: 000409316200011PubMedID: 28257339Scopus ID: 2-s2.0-85014228327OAI: oai:DiVA.org:liu-146343DiVA, id: diva2:1195974
Available from: 2018-04-07 Created: 2018-04-07 Last updated: 2018-04-19Bibliographically approved

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Warntjes, Marcel, Jan Bertus

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Warntjes, Marcel, Jan Bertus
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Division of Cardiovascular MedicineFaculty of Medicine and Health SciencesCenter for Medical Image Science and Visualization (CMIV)Department of Clinical Physiology in Linköping
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