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A ß-Glucan-Based Dietary Fiber Reduces Mast Cell-Induced Hyperpermeability in Ileum From Patients With Crohns Disease and Control Subjects
School of Medical Sciences, Nutrition-Gut-Brain Interactions Research Centre, Örebro University, Örebro, Sweden.
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences.
School of Medical Sciences, Nutrition-Gut-Brain Interactions Research Centre, Örebro University, Örebro, Sweden.
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2018 (English)In: Inflammatory Bowel Diseases, ISSN 1078-0998, E-ISSN 1536-4844, Vol. 24, no 1, p. 166-178Article in journal (Refereed) Published
Abstract [en]

Administration of ß-glucan has shown immune-enhancing effects. Our aim was to investigate whether ß-glucan could attenuate mast cell (MC)-induced hyperpermeability in follicle-associated epithelium (FAE) and villus epithelium (VE) of patients with Crohns disease (CD) and in noninflammatory bowel disease (IBD)-controls. Further, we studied mechanisms of ß-glucan uptake and effects on MCs in vitro.
Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2018. Vol. 24, no 1, p. 166-178
Keyword [en]
Crohn’s disease; intestinal permeability; ß-glucan
National Category
Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:liu:diva-146363DOI: 10.1093/ibd/izx002ISI: 000427524400018PubMedID: 29272475OAI: oai:DiVA.org:liu-146363DiVA, id: diva2:1195985
Available from: 2018-04-07 Created: 2018-04-07 Last updated: 2018-04-07

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Winberg, Martin E.Keita, Åsa

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Casado-Bedmar, MaiteWinberg, Martin E.Keita, Åsa
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Department of Clinical and Experimental MedicineFaculty of Medicine and Health SciencesDivision of Surgery, Orthopedics and Oncology
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Inflammatory Bowel Diseases
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