A ß-Glucan-Based Dietary Fiber Reduces Mast Cell-Induced Hyperpermeability in Ileum From Patients With Crohns Disease and Control SubjectsShow others and affiliations
2018 (English)In: Inflammatory Bowel Diseases, ISSN 1078-0998, E-ISSN 1536-4844, Vol. 24, no 1, p. 166-178Article in journal (Refereed) Published
Abstract [en]
Administration of ß-glucan has shown immune-enhancing effects. Our aim was to investigate whether ß-glucan could attenuate mast cell (MC)-induced hyperpermeability in follicle-associated epithelium (FAE) and villus epithelium (VE) of patients with Crohns disease (CD) and in noninflammatory bowel disease (IBD)-controls. Further, we studied mechanisms of ß-glucan uptake and effects on MCs in vitro.
Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2018. Vol. 24, no 1, p. 166-178
Keywords [en]
Crohn’s disease; intestinal permeability; ß-glucan
National Category
Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:liu:diva-146363DOI: 10.1093/ibd/izx002ISI: 000427524400018PubMedID: 29272475OAI: oai:DiVA.org:liu-146363DiVA, id: diva2:1195985
2018-04-072018-04-072025-02-11