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C-reactive protein response patterns after antibiotic treatment among children with scalds
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery.
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery.
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery. Suez Canal University, Ismailia, Egypt.
2018 (English)In: Burns, ISSN 0305-4179, E-ISSN 1879-1409, Vol. 44, p. 718-723Article in journal (Refereed) Published
Abstract [en]

Background

Scalds are the most common cause of burns in children, yet there is little information available about the inflammatory response. The aim of the study was to investigate the response to treatment with antibiotics among scalded children by following the C-reactive protein (CRP) concentration, procalcitonin (PCT) concentration, and white blood cell count (WCC) during the first two weeks after injury.

Methods

All children with scalds who presented to the Burn Centre during 2010–2016 were included in this retrospective study. All measurements of CRP, PCT, and WCC from the first 14 days after injury were recorded, and each patient’s maximum values during days 0–2, 3–7, and 8–14 were used for calculations. Multivariable regression for panel data was used to study the inflammatory response after antibiotic treatment.

Results

A total of 216 children were included. C-reactive protein was 45 mg/L (p < 0.001) higher in the group treated with antibiotics, and decreased with 8.8 mg/L per day over the studied time in this group, which was more than twice as fast as among the children who were not given antibiotics.

Conclusion

The CRP response, among children with minor scalds treated with antibiotics, shows an appreciable rise during the first week of injury that subsided rapidly during the second week.

Place, publisher, year, edition, pages
Pergamon Press, 2018. Vol. 44, p. 718-723
Keywords [en]
Burns, C-reactive protein, Inflammatory response, Procalcitonin, White blood cell count, Antibiotics
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:liu:diva-147069DOI: 10.1016/j.burns.2017.10.023ISI: 000430054700029PubMedID: 29571718Scopus ID: 2-s2.0-85044143191OAI: oai:DiVA.org:liu-147069DiVA, id: diva2:1196947
Note

Funding agencies: Department of Hand Surgery, Plastic Surgery, and Burns; Linkoping University, Linkoping, Sweden

Available from: 2018-04-11 Created: 2018-04-11 Last updated: 2018-05-14Bibliographically approved

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Steinvall, IngridKarlsson, MatildaElmasry, Moustafa

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Division of Surgery, Orthopedics and OncologyFaculty of Medicine and Health SciencesDepartment of Hand and Plastic Surgery
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