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FBI-1 mRNA in normal mucosa is an independent prognostic factor in colorectal cancer patients
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Oncology. Henan Univ, Peoples R China.
Henan Univ, Peoples R China.
Henan Univ, Peoples R China.
Henan Univ, Peoples R China.
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2018 (English)In: International Journal of Clinical and Experimental Pathology, ISSN 1936-2625, E-ISSN 1936-2625, Vol. 11, no 2, p. 642-649Article in journal (Refereed) Published
Abstract [en]

Although several studies provide evidence that FBI-1 is an important gene regulator in colorectal cancer (CRC), it is noteworthy that, to our knowledge, no analysis of the correlation between FBI-1 expression and prognosis in CRC has been reported. Using real-time RT-PCR, we detected FBI-1 mRNA in 161 CRC patients (primary tumor, along with the corresponding normal mucosa), 36 liver metastases, and analyzed the relationship of its expression with clinicopathological features. Colon cancer cell lines were used to study FBI-1 function. Our study found that FBI-1 was significant up-regulated in tumor tissue (2.621 +/- 0.157) compared with the corresponding normal mucosa (1.620 +/- 0.165, P amp;lt; 0.0001). FBI-1 in normal mucosa was a prognostic factor (P = 0.039, RR 0.431, 95% CI 0.194-0.958), independent of gender, age, stage, and differentiation. High levels of FBI-1 mRNA were related with good survival. Patients with complications had a higher primary tumor FBI-1 expression than those without complications (3.400 +/- 0.332 vs. 2.516 +/- 0.241, P = 0.032). Suppression of FBI-1 in colon cancer cell lines could repress proliferation of cancer cells. In conclusion, FBI-1 mRNA is overexpressed in CRC, and takes part in the development of CRC. FBI-1 mRNA in normal mucosa is an independent prognostic factor. Our findings give further support to the concept of "field cancerization", and hint that when we study a biomarker, we should not only focus on the tumor tissue but also the corresponding normal mucosa.

Place, publisher, year, edition, pages
E-CENTURY PUBLISHING CORP , 2018. Vol. 11, no 2, p. 642-649
Keywords [en]
Colorectal cancer; FBI-1; prognosis; biomarker; field cancerization
National Category
Surgery
Identifiers
URN: urn:nbn:se:liu:diva-147179ISI: 000427096500019OAI: oai:DiVA.org:liu-147179DiVA, id: diva2:1197275
Note

Funding Agencies|Swedish Cancer Foundation; Swedish Research Council; Health Research Council in Southeast Sweden; National Natural Science Foundation of China [U1204818]; Projects of Science and Technology in Henan Province [172102310064, 142102210094]

Available from: 2018-04-12 Created: 2018-04-12 Last updated: 2018-05-14

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Wang, ChaojieSun, Xiao-Feng
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Division of Surgery, Orthopedics and OncologyFaculty of Medicine and Health SciencesDepartment of Oncology
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