liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Variant ribosomal RNA alleles are conserved and exhibit tissue-specific expression
Weill Cornell Med, NY 10065 USA.
Weill Cornell Med, NY 10065 USA.
Weill Cornell Med, NY 10065 USA.
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Weill Cornell Med, NY 10065 USA; Karolinska Inst, Sweden.
Show others and affiliations
2018 (English)In: Science Advances, ISSN 0036-8156, E-ISSN 2375-2548, Vol. 4, no 2, article id eaao0665Article in journal (Refereed) Published
Abstract [en]

The ribosome, the integration point for protein synthesis in the cell, is conventionally considered a homogeneous molecular assembly that only passively contributes to gene expression. Yet, epigenetic features of the ribosomal DNA (rDNA) operon and changes in the ribosomes molecular composition have been associated with disease phenotypes, suggesting that the ribosome itself may possess inherent regulatory capacity. Analyzing whole-genome sequencing data from the 1000 Genomes Project and the Mouse Genomes Project, we find that rDNA copy number varies widely across individuals, and we identify pervasive intra-and interindividual nucleotide variation in the 5S, 5.8S, 18S, and 28S ribosomal RNA (rRNA) genes of both human and mouse. Conserved rRNA sequence heterogeneities map to functional centers of the assembled ribosome, variant rRNA alleles exhibit tissue-specific expression, and ribosomes bearing variant rRNA alleles are present in the actively translating ribosome pool. These findings provide a critical framework for exploring the possibility that the expression of genomically encoded variant rRNA alleles gives rise to physically and functionally heterogeneous ribosomes that contribute to mammalian physiology and human disease.

Place, publisher, year, edition, pages
AMER ASSOC ADVANCEMENT SCIENCE , 2018. Vol. 4, no 2, article id eaao0665
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:liu:diva-147167DOI: 10.1126/sciadv.aao0665ISI: 000426845500013PubMedID: 29503865OAI: oai:DiVA.org:liu-147167DiVA, id: diva2:1199470
Note

Funding Agencies|Tri-Institutional Stem Cell Initiative by the Starr Foundation; NIH [GM079238]; Jacques Cohenca Predoctoral Fellowship

Available from: 2018-04-20 Created: 2018-04-20 Last updated: 2018-06-03

Open Access in DiVA

fulltext(1267 kB)92 downloads
File information
File name FULLTEXT01.pdfFile size 1267 kBChecksum SHA-512
45678675e5294e4f7117b9e0483154165adeb66da466edd87937cb9e43d70e8ebb51131017d71e4037e3a0b9a041bcd7563e9f7eeec2cdd1cce9ba5ec45f4c3b
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Bojmar, Linda
By organisation
Division of Surgery, Orthopedics and OncologyFaculty of Medicine and Health Sciences
In the same journal
Science Advances
Cell and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar
Total: 92 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 155 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf