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On modelling and simulation of the human cardiovascular system: with special reference to aortic coarctation and mitral regurgitation
Linköping University, Department of Mechanical Engineering, Fluid and Mechanical Engineering Systems. Linköping University, The Institute of Technology.ORCID iD: 0000-0001-5526-2399
1992 (English)Licentiate thesis, comprehensive summary (Other academic)
Abstract [en]

In this thesis the method of identification has been proposed for interpreting data obatined from pressure measurement on patients with aortic coarctation. In order to investigate its charcteristics and applicability the algortithm for identification was initially tested using a simple model of the human cardiovascular system.

A more accurate description of an aortic segment was thus developed. The model is based on an existing model for an elastic tube, which was generalized into a description for a tube with visco-elastic walls. The visco-elastic behaviour of the wall is then modelled in the same sence as the viscosity in the fluid itself.

The PISA-method for quantifying mitral regurgitation has been theoretically analysed. The purpose was to analyse the foundations of the PISA­ method: The flow through an orifice may be estimated by multiplying the center line velocity with the assumed hemispherical area. The calculations were also compared with experimental measurements. By using computer simulations, experimental measurements and clinical observations a better insight into the hemodynamics is obtained as well as an increased understanding of the shortcomings of the measurement technique under consideration.

Place, publisher, year, edition, pages
Linköping: Linköpings universitet , 1992. , p. 98
Series
Linköping Studies in Science and Technology. Thesis, ISSN 0280-7971 ; 353
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-145874Local ID: LiU-TEK-LIC-1992:45ISBN: 9178710464 (print)OAI: oai:DiVA.org:liu-145874DiVA, id: diva2:1201256
Available from: 2018-04-25 Created: 2018-04-25 Last updated: 2018-10-30Bibliographically approved

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Karlsson, Matts

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