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Microtechnology applied to stem cells research and development
Univ Los Andes, Chile; Cells Cells, Chile.
Univ Los Andes, Chile; Cells Cells, Chile.
Linköping University, Department of Physics, Chemistry and Biology, Biotechnology. Linköping University, Faculty of Science & Engineering. Univ Los Andes, Chile.
Univ Los Andes, Chile; Cells Cells, Chile; Consorcio Regenero, Chile.
2018 (English)In: Regenerative Medicine, ISSN 1746-0751, E-ISSN 1746-076X, Vol. 13, no 2, p. 233-248Article, review/survey (Refereed) Published
Abstract [en]

Microfabrication and microfluidics contribute to the research of cellular functions of cells and their interaction with their environment. Previously, it has been shown that microfluidics can contribute to the isolation, selection, characterization and migration of cells. This review aims to provide stem cell researchers with a toolkit of microtechnology (mT) instruments for elucidating complex stem cells functions which are challenging to decipher with traditional assays and animal models. These microdevices are able to investigate about the differentiation and niche interaction, stem cells transcriptomics, therapeutic functions and the capture of their secreted microvesicles. In conclusion, microtechnology will allow a more realistic assessment of stem cells properties, driving and accelerating the translation of regenerative medicine approaches to the clinic.

Place, publisher, year, edition, pages
FUTURE MEDICINE LTD , 2018. Vol. 13, no 2, p. 233-248
Keywords [en]
cancer; differentiation; microfabrication; microfluidics; microtechnology; regenerative medicine; stem cells; translational medicine
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:liu:diva-147586DOI: 10.2217/rme-2017-0123ISI: 000429622800010PubMedID: 29557299OAI: oai:DiVA.org:liu-147586DiVA, id: diva2:1201800
Note

Funding Agencies|Chilean Ministry of Economy with its CORFO grant [3IDL2-18745]; PMI fund - Chilean Ministry of Education [UAN1301]; Cells for Cells

Available from: 2018-04-26 Created: 2018-04-26 Last updated: 2018-04-26

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CiteExportLink to record
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Citation style
  • apa
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  • Other style
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Language
  • de-DE
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Output format
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