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Reversible Self-Assembled Monolayers (rSAMs) as Robust and Fluidic Lipid Bilayer Mimics
Malmo Univ, Sweden; Malmo Univ, Sweden.
Linköping University, Department of Physics, Chemistry and Biology, Molecular Physics. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0002-1639-5735
Malmö Univ, Sweden.
Malmö Univ, Sweden.
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2018 (English)In: Langmuir, ISSN 0743-7463, E-ISSN 1520-5827, Vol. 34, no 13, p. 4107-4115Article in journal (Refereed) Published
Abstract [en]

Lipid bilayers, forming the outer barrier of cells, display a wide array of proteins and carbohydrates for modulating interfacial biological interactions. Formed by the spontaneous self-assembly of lipid molecules, these bilayers feature liquid crystalline order, while retaining a high degree of lateral mobility. Studies of these dynamic phenomena have been hampered by the fragility and instability of corresponding biomimetic cell membrane models. Here, we present the construct of a series of oligoethylene glycol-terminated reversible self-assembled monolayers (rSAMs) featuring lipid-bilayer-like fluidity, while retaining air and protein stability and resistance. These robust and ordered layers were prepared by simply immersing a carboxylic acid terminated self-assembled monolayer into 5-50 mu M aqueous omega-(4-ethylene glycol-phenoxy)-alpha-(4-amidinophenoxy)decane solutions. It is anticipated that this new class of robust and fluidic two-dimensional biomimetic surfaces will impact the design of rugged cell surface mimics and high-performance biosensors.

Place, publisher, year, edition, pages
AMER CHEMICAL SOC , 2018. Vol. 34, no 13, p. 4107-4115
National Category
Physical Chemistry
Identifiers
URN: urn:nbn:se:liu:diva-147563DOI: 10.1021/acs.langmuir.8b00226ISI: 000429385100037PubMedID: 29553755OAI: oai:DiVA.org:liu-147563DiVA, id: diva2:1201957
Note

Funding Agencies|Swedish Research Council [C0296601]; Marie Sklodowska-Curie Actions [658953]; Gustaf Th. Ohlsson Foundation

Available from: 2018-04-27 Created: 2018-04-27 Last updated: 2018-04-27

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