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Evaluation of the immunogenic capability of the BCG strains BCG Delta BCG1419c and BCG Delta BCG1416c in a three-dimensional human lung tissue model
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
Ctr Invest and Asistencia Tecnol and Diseno Estado Ja, Mexico.
Ctr Invest and Asistencia Tecnol and Diseno Estado Ja, Mexico.
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2018 (English)In: Vaccine, ISSN 0264-410X, E-ISSN 1873-2518, Vol. 36, no 14, p. 1811-1815Article in journal (Refereed) Published
Abstract [en]

Tuberculosis (TB) still remains as an unmet global threat. The current vaccine is not fully effective and novel alternatives are needed. Here, two vaccine candidate strains derived from BCG carrying deletions in the BCG1416c or BCG1419c genes were analysed for their capacity to modulate the cytoldne/chemokine profile and granuloma formation in a human lung tissue model (LTM). We show that the clustering of monocytes, reminiscent of early granuloma formation, in LTMs infected with BCG strains was similar for all of them. However, BCG Delta BCG1419c, like M. tuberculosis, was capable of inducing the production of IL-6 in contrast to the other BCG strains. This work suggests that LTM could be a useful ex vivo assay to evaluate the potential immunogenicity of novel TB vaccine candidates.

Place, publisher, year, edition, pages
Elsevier, 2018. Vol. 36, no 14, p. 1811-1815
Keywords [en]
Bacillus Calmette-Guerin; Tuberculosis; Granulomas; Immunogenicity; Vaccine
National Category
Microbiology in the medical area
Identifiers
URN: urn:nbn:se:liu:diva-147814DOI: 10.1016/j.vaccine.2018.02.044ISI: 000429393100004PubMedID: 29475763Scopus ID: 2-s2.0-85042182762OAI: oai:DiVA.org:liu-147814DiVA, id: diva2:1205625
Note

Funding Agencies|Swedish Research Council [2014-02289]; CONACYT [86396, 432019, 348657]; CIATEJs funds

Available from: 2018-05-14 Created: 2018-05-14 Last updated: 2018-05-22Bibliographically approved

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Venkata Ramanarao, ParasaRose, JeronimoLerm, Maria
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