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Immune profile in relation to sex steroid cyclicity in healthy women and women with multiple sclerosis
Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences. Cty Hosp Sundsvall, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.
Not Found:Linkoping Univ, Dept Clin and Expt Med, SE-58185 Linkoping, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center of Paediatrics and Gynaecology and Obstetrics, Department of Gynaecology and Obstetrics in Linköping.
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2018 (English)In: Journal of Reproductive Immunology, ISSN 0165-0378, E-ISSN 1872-7603, Vol. 126, p. 53-59Article in journal (Refereed) Published
Abstract [en]

To prospectively study systemic in vivo immunological effects of sex hormones, using different phases of oral combined hormonal contraceptives (CHC), and the natural menstrual cycles in both healthy women and in women with multiple sclerosis (MS), blood samples from sixty female MS patients and healthy controls with and without CHC were drawn in high and low estrogenic/progestogenic phases. Expression of Th-associated genes in blood cells was determined by qPCR and a panel of cytokines and chemokines was measured in plasma. High hormone level phases were associated with increases in Th1 (TBX21) and Th2 (GATA3) associated markers, as well as the B cell-associated chemokine CXCL13, while the inhibitory regulator CTLA-4 was decreased. These changes were not observed in MS patients, of whom most were treated with immunomodulatory drugs. Our data indicate immune activating properties in vivo of high steroid sex hormone levels during both CHC and normal menstrual cyclicity.

Place, publisher, year, edition, pages
ELSEVIER IRELAND LTD , 2018. Vol. 126, p. 53-59
Keywords [en]
Contraception; Immunology; Estrogen; Progesterone; Multiple sclerosis; Menstrual cycle
National Category
Immunology
Identifiers
URN: urn:nbn:se:liu:diva-147812DOI: 10.1016/j.jri.2018.02.006ISI: 000430033900008PubMedID: 29501895OAI: oai:DiVA.org:liu-147812DiVA, id: diva2:1205628
Note

Funding Agencies|Swedish Research Council [K2013-61X-22310-01-04]; County Council of Ostergotland; County Council of Vasternorrland

Available from: 2018-05-14 Created: 2018-05-14 Last updated: 2018-05-31

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Kempe, PerEklund, DanielHammar, MatsBrynhildsen, JanErnerudh, Jan
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Division of Children's and Women's healthFaculty of Medicine and Health SciencesDivision of Neuro and Inflammation ScienceDepartment of Gynaecology and Obstetrics in LinköpingDepartment of Clinical Immunology and Transfusion Medicine
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Journal of Reproductive Immunology
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