liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Oxytocin Reduces Alcohol Cue-Reactivity in Alcohol-Dependent Rats and Humans
Heidelberg Univ, Germany.
Heidelberg Univ, Germany.
Heidelberg Univ, Germany.
Heidelberg Univ, Germany.
Show others and affiliations
2018 (English)In: Neuropsychopharmacology, ISSN 0893-133X, E-ISSN 1740-634X, Vol. 43, no 6, p. 1235-1246Article in journal (Refereed) Published
Abstract [en]

Approved pharmacological treatments for alcohol use disorder are limited in their effectiveness, and new drugs that can easily be translated into the clinic are warranted. One of those candidates is oxytocin because of its interaction with several alcohol-induced effects. Alcoholdependent rats as well as post-mortem brains of human alcoholics and controls were analyzed for the expression of the oxytocin system by qRT-PCR, in situ hybridizaton, receptor autoradiography ([(125)l]OVTA binding), and immunohistochemistry. Alcohol self administration and cue-induced reinstatement behavior was measured after intracerebroventicular injection of 10 nM oxytocin in dependent rats. Here we show a pronounced upregulation of oxytocin receptors in brain tissues of alcohol dependent rats and deceased alcoholics, primarily in frontal and striatal areas. This upregulation stems most likely from reduced oxytocin expression in hypothalamic nuclei. Pharmacological validaton showed that oxytocin reduced cue-induced reinstatement response in dependent rats-an effect that was not observed in nondependent rats. Finally, a clinical pilot study (German clinical trial number DRKS00009253) using functional magnetic resonance imaging in heavy social male drinkers showed that intranasal oxytocin (24 IU) decreased neural cue-reactivity in brain networks similar to those detected in dependent rats and humans with increased oxytocin receptor expression. These studies suggest that oxytocin might be used as an anticraving medication and thus may positvely affect treatment outcomes in alcoholics.

Place, publisher, year, edition, pages
NATURE PUBLISHING GROUP , 2018. Vol. 43, no 6, p. 1235-1246
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:liu:diva-147792DOI: 10.1038/npp.2017.257ISI: 000430415100007PubMedID: 29090683OAI: oai:DiVA.org:liu-147792DiVA, id: diva2:1206493
Note

Funding Agencies|Bundesministerium fur Bildung und Forschung [FKZ: 01ZX1311A, 01 EE 1406 C]; Deutsche Forschungsgemeinschaft [SFB1134, DFG HA6102/1-1]; European Unions Horizon research and innovation program [668863]

Available from: 2018-05-17 Created: 2018-05-17 Last updated: 2018-05-17

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Domi, Esi
By organisation
Center for Social and Affective NeuroscienceFaculty of Medicine and Health Sciences
In the same journal
Neuropsychopharmacology
Neurosciences

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 71 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf