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Supplemental oxygen therapy does not affect the systemic inflammatory response to acute myocardial infarction
Soder Sjukhuset, Sweden.
Soder Sjukhuset, Sweden.
Soder Sjukhuset, Sweden.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Cardiology in Linköping.
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2018 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 283, no 4, p. 334-345Article in journal (Refereed) Published
Abstract [en]

Background. Oxygen therapy has been used routinely in normoxemic patients with suspected acute myocardial infarction (AMI) despite limited evidence supporting a beneficial effect. AMI is associated with a systemic inflammation. Here, we hypothesized that the inflammatory response to AMI is potentiated by oxygen therapy. Methods. The DETermination of the role of Oxygen in suspected Acute Myocardial Infarction (DETO2X-AMI) multicentre trial randomized patients with suspected AMI to receive oxygen at 6 L min(-1) for 6-12 h or ambient air. For this prespecified subgroup analysis, we recruited patients with confirmed AMI from two sites for evaluation of inflammatory biomarkers at randomization and 5-7 h later. Ninety-two inflammatory biomarkers were analysed using proximity extension assay technology, to evaluate the effect of oxygen on the systemic inflammatory response to AMI. Results. Plasma from 144 AMI patients was analysed whereof 76 (53%) were randomized to oxygen and 68 (47%) to air. Eight biomarkers showed a significant increase, whereas 13 were decreased 5-7 h after randomization. The inflammatory response did not differ between the two treatment groups neither did plasma troponin T levels. After adjustment for increase in troponin T over time, age and sex, the release of inflammation-related biomarkers was still similar in the groups. Conclusions. In a randomized controlled setting of normoxemic patients with AMI, the use of supplemental oxygen did not have any significant impact on the early release of systemic inflammatory markers.

Place, publisher, year, edition, pages
WILEY , 2018. Vol. 283, no 4, p. 334-345
Keywords [en]
acute myocardial infarction; biomarker; cytokine; inflammation; reactive oxygen species
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:liu:diva-147403DOI: 10.1111/joim.12716ISI: 000428438600001PubMedID: 29226465OAI: oai:DiVA.org:liu-147403DiVA, id: diva2:1206694
Note

Funding Agencies|Swedish Research Council; Swedish Heart-Lung Foundation; Swedish Foundation for Strategic Research

Available from: 2018-05-17 Created: 2018-05-17 Last updated: 2018-05-17

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Alfredsson, JoakimJonasson, LenaNilsson, Lennart
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Division of Cardiovascular MedicineFaculty of Medicine and Health SciencesDepartment of Cardiology in Linköping
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  • apa
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  • de-DE
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