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Dose-response of somatosensory cortex repeated anodal transcranial direct current stimulation on vibrotactile detection: A randomized sham controlled trial
Faculty of Health Science and Medicine, Bond University, Gold Coast, Queensland, Australia.
Faculty of Health Science and Medicine, Bond University, Gold Coast, Queensland, Australia.
Faculty of Health Science and Medicine, Bond University, Gold Coast, Queensland, Australia.
Linköping University, Department of Medical and Health Sciences, Division of Physiotherapy. Linköping University, Faculty of Medicine and Health Sciences. Faculty of Health Science and Medicine, Bond University, Gold Coast, Queensland, Australia.ORCID iD: 0000-0002-4318-9216
2018 (English)In: Journal of Neurophysiology, ISSN 0022-3077, E-ISSN 1522-1598Article in journal (Refereed) Published
Abstract [en]

This randomized sham-controlled trial investigated anodal transcranial direct current stimulation (tDCS) over the somatosensory cortex contralateral to hand dominance for dose-response (1mA-20 minutes x 5 days) effects on vibrotactile detection thresholds (VDT). VDT was measured before and after tDCS on days 1,3&5 for low (30hz) and high (200hz) frequency vibrations on the dominant and non-dominant hands in 29 healthy adults (mean age = 22.86; 15 males, 14 females). Only the dominant hand 200Hz VDT displayed statistically significant medium effect size improvement for mixed model analysis of variance time x group interaction for active tDCS compared to sham. Post Hoc contrasts were statistically significant for dominant hand 200Hz VDT on day 5 after tDCS compared to day 1 before tDCS , day 1 after tDCS and day 3 before tDCS. There was a linear dose-response improvement with dominant hand 200Hz VDT mean difference decreasing from day 1 before tDCS peaking at -15.5% (SD=34.9%) on day 5 after tDCS. Both groups showed learning effect trends over time for all VDT test conditions but only the non-dominant hand 30Hz VDT was statistically significant (p=0.03) though Post Hoc contrasts were non-significant after Sidak adjustment. No adverse effects for tDCS were reported. In conclusion, anodal tDCS 1mA-20 minutes x 5 days on the dominant sensory cortex can modulate a linear improvement of dominant hand high frequency VDT but not for low frequency or non-dominant hand VDT.

Place, publisher, year, edition, pages
Bethesda, United States: American Physiological Society , 2018.
Keywords [en]
Transcranial direct current stimulation, primary somatosensory cortex, vibrotactile detection threshold
National Category
Physiology
Identifiers
URN: urn:nbn:se:liu:diva-147878DOI: 10.1152/jn.00926.2017ISI: 000441195200019PubMedID: 29726731OAI: oai:DiVA.org:liu-147878DiVA, id: diva2:1206905
Available from: 2018-05-18 Created: 2018-05-18 Last updated: 2018-08-24Bibliographically approved

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Abbott, Allan

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