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A reversible and highly selective two-photon fluorescent "on-off-on" probe for biological Cu2+ detection
Wannan Med Coll, Peoples R China.
Anhui Univ, Peoples R China.
Wannan Med Coll, Peoples R China.
Wannan Med Coll, Peoples R China.
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2018 (English)In: Organic and biomolecular chemistry, ISSN 1477-0520, E-ISSN 1477-0539, Vol. 16, no 13, p. 2264-2268Article in journal (Refereed) Published
Abstract [en]

A two-photon active probe for physiological copper (Cu2+) detection is expected to play an important role in monitoring biological metabolism. Herein, a novel Schiff base derivative (E)-2,2-((4-((4-(diethylamino)-2-hydroxybenzylidene)amino)phenyl)azanediyl)bis(ethan-1-ol) (L) with remarkable two-photon activity was developed and synthetically investigated. L presents high selectivity and sensitivity for Cu2+ sensing in ethanol/HEPES buffer (v/v, 1:1), which is accompanied by the fluorescence switching off and subsequently on with the addition of EDTA. The mechanism for the detection of Cu2+ is further analyzed using H-1 NMR titration, mass spectra and theoretical calculations. Furthermore, since the probe L possesses good photophysical properties, excellent biocompatibility and low cytotoxicity, it is successfully applied to track Cu2+ in the cellular endoplasmic reticulum by two-photon fluorescence imaging, showing its potential value for practical applications in biological systems.

Place, publisher, year, edition, pages
ROYAL SOC CHEMISTRY , 2018. Vol. 16, no 13, p. 2264-2268
National Category
Organic Chemistry
Identifiers
URN: urn:nbn:se:liu:diva-147380DOI: 10.1039/c8ob00257fISI: 000428671200009PubMedID: 29532844OAI: oai:DiVA.org:liu-147380DiVA, id: diva2:1207022
Note

Funding Agencies|Natural Science Foundation of Anhui Province [1508085SMB208]; Doctoral Startup Foundation of Wannan Medical College [wYRCQD201715]; Educational Commission of Anhui Province of China [KJ2016A788]; Swedish Government Strategic Research Area in Materials Science on Functional Materials at Linkoping University (Faculty Grant SFO-Mat-LiU) [2009-00971]

Available from: 2018-05-18 Created: 2018-05-18 Last updated: 2018-06-05

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