liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Label-free DNA sensor based on diazonium immobilisation for detection of DNA damage in breast cancer 1 gene
Linköping University, Department of Physics, Chemistry and Biology, Sensor and Actuator Systems. Linköping University, Faculty of Science & Engineering. Eletroanalytical Chemistry Research Laboratory, Department of Analytical Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran.
Eletroanalytical Chemistry Research Laboratory, Department of Analytical Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran.
Linköping University, Department of Physics, Chemistry and Biology, Sensor and Actuator Systems. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0002-1815-9699
Eletroanalytical Chemistry Research Laboratory, Department of Analytical Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran.
Show others and affiliations
2018 (English)In: Sensors and actuators. B, Chemical, ISSN 0925-4005, E-ISSN 1873-3077, Vol. 264, p. 59-66Article in journal (Refereed) Published
Abstract [en]

Electrochemical DNA biosensors offer simple and rapid tools for detection of DNA sequences or damaged genes associated with human disease. The performance of electrochemical DNA sensors is critically dependent on the quality of the DNA immobilisation. Many DNA biosensors have been focused on studying DNA hybridisation preformed under relatively mild assay conditions, while the development of stable DNA biosensors to study DNA damage under a much harsher condition typically in the presence of reactive oxygen species is more challenging. In this article, we developed an electrochemical DNA biosensor based on a stable diazonium-modified screen-printed carbon electrode (SPCE) for the detection of damage in DNA sequences related to the BRCA1 gene by using electrochemical impedance spectroscopy (EIS). The successful preparation of the DNA sensor was confirmed by FTIR-ATR, contact angle and electrochemical measurements. The DNA sensor exhibited good reproducibility and high stability and could also have potential for investigation of the glutathione antioxidant effect. (C) 2018 Elsevier B.V. All rights reserved.

Place, publisher, year, edition, pages
Elsevier, 2018. Vol. 264, p. 59-66
Keywords [en]
Screen-printed carbon electrode; DNA damage; Electrochemical impedance spectroscopy; Diazonium immobilisation
National Category
Analytical Chemistry
Identifiers
URN: urn:nbn:se:liu:diva-147362DOI: 10.1016/j.snb.2018.02.152ISI: 000428032900008Scopus ID: 2-s2.0-85042716531OAI: oai:DiVA.org:liu-147362DiVA, id: diva2:1207077
Available from: 2018-05-18 Created: 2018-05-18 Last updated: 2018-05-30Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textScopus

Search in DiVA

By author/editor
Mousavisani, Seyedeh ZeinabTurner, AnthonyMak, Wing Cheung
By organisation
Sensor and Actuator SystemsFaculty of Science & Engineering
In the same journal
Sensors and actuators. B, Chemical
Analytical Chemistry

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 136 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf