liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Characteristics of slow progression to diabetes in multiple islet autoantibody-positive individuals from five longitudinal cohorts: the SNAIL study
Univ Bristol, England.
Univ Bristol, England.
Univ Pittsburgh, PA 15260 USA.
Univ Pittsburgh, PA 15260 USA.
Show others and affiliations
2018 (English)In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 61, no 6, p. 1484-1490Article in journal (Refereed) Published
Abstract [en]

Aims/hypothesis Multiple islet autoimmunity increases risk of diabetes, but not all individuals positive for two or more islet autoantibodies progress to disease within a decade. Major islet autoantibodies recognise insulin (IAA), GAD (GADA), islet antigen-2 (IA-2A) and zinc transporter 8 (ZnT8A). Here we describe the baseline characteristics of a unique cohort of slow progressors (n = 132) who were positive for multiple islet autoantibodies (IAA, GADA, IA-2A or ZnT8A) but did not progress to diabetes within 10 years. Methods Individuals were identified from five studies (BABYDIAB, Germany; Diabetes Autoimmunity Study in the Young [DAISY], USA; All Babies in Southeast Sweden [ABIS], Sweden; Barts Oxford Family Study [BOX], UK and the Pittsburgh Family Study, USA). Multiple islet autoantibody characteristics were determined using harmonised assays where possible. HLA class II risk was compared between slow progressors and rapid progressors (n = 348 diagnosed amp;lt; 5 years old from BOX) using the chi(2) test. Results In the first available samples with detectable multiple antibodies, the most frequent autoantibodies were GADA (92%), followed by ZnT8A (62%), IAA (59%) and IA-2A (41%). High risk HLA class II genotypes were less frequent in slow (28%) than rapid progressors (42%, p = 0.011), but only two slow progressors carried the protective HLA DQ6 allele. Conclusion No distinguishing characteristics of slow progressors at first detection of multiple antibodies have yet been identified. Continued investigation of these individuals may provide insights into slow progression that will inform future efforts to slow or prevent progression to clinical diabetes.

Place, publisher, year, edition, pages
SPRINGER , 2018. Vol. 61, no 6, p. 1484-1490
Keywords [en]
HLA class II; Islet autoantibodies; Slow progression; Type 1 diabetes
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:liu:diva-147895DOI: 10.1007/s00125-018-4591-5ISI: 000431650800024PubMedID: 29532109OAI: oai:DiVA.org:liu-147895DiVA, id: diva2:1209637
Note

Funding Agencies|Diabetes UK-Fulbright Award; Diabetes UK Moffat Travelling Fellowship [13/0004636]; Diabetes UK [14/0004869]; JDRF [17-2013-529, 17-2013-535]; Deutsche Forschungsgemeinschaft (DFG) [ZI-310/14-1]; National Institutes of Health (NIH) [R01 DK32083, DK32493]; Vetenskapsradet; Novo Nordisk; Barndiabetesfonden; ALF grants; Region Ostergotland and Medical Research Council of southeast Sweden (Forskningsradet i sydostrasverige, FORSS) [12594]; NIH [R01 DK53456, DK56200, R01 DK24021]; NIDDK [PA-04-081]; Brehm Coalition by the University of Michigan Center for Computational Medicine and Biology Pilot Research Program NIH Grant [R01 DK46864]; General Clinical Research Center of the Childrens Hospital of Pittsburgh Grant [MO1 RR 00084]; Renziehausen fund

Available from: 2018-05-23 Created: 2018-05-23 Last updated: 2019-05-01

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Authority records BETA

Ludvigsson, Johnny

Search in DiVA

By author/editor
Casas, RosauraLudvigsson, Johnny
By organisation
Division of Children's and Women's healthFaculty of Medicine and Health SciencesH.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus
In the same journal
Diabetologia
Endocrinology and Diabetes

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 82 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf