Throughout the history of Science Parks, many studies have shown that Science Parks have ceased to be mere facilitators of physical spaces, to become important providers of services and resources to their tenants. Considering that skilled professionals are one of the most sought after resources by technology and knowledge intensive firms, Science Parks have dedicated numerous activities and means in order to become even more attractive to talents. In this context, universities situated in or next to Science Parks play a key role in developing and attracting talents to Science Parks and to its firms as well as to the region, functioning as a regional node of a large national and international network of universities. Science Parks and universities are vital parts of the entrepreneurial ecosystem of a region and have many complementarities. In this study, we review the literature regarding the relationship existing between Science Parks and universities and the ways in which they can collaborate. Talent, recruitment, and entrepreneurship issues are addressed as the building blocks of these interactions. Other stakeholders, inside and outside a Science Park, are also analysed in order to widen the perspective to the ecosystem of actors involved, allowing a better understanding of the role, the interests, the means and the implications of each one. The purpose of this study is to understand and qualify the university's role in attracting and developing talent that firms in Science Parks can recruit later on. We identify the types of interactions occurring between Science Parks and their nearby universities. We strive to find what kinds of skills are considered relevant by employers, and to describe the initiatives developed by universities and Science Parks – separately and together – aiming at drawing, developing and retaining talents. We also seek to identify who are the actors involved; private or public organisations, or people embodying specific functions in these organisations. In the end, we recognize and point out policy implications, concerning both universities and Science Parks.