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TEXT messages to improve MEDication adherence and Secondary prevention (TEXTMEDS) after acute coronary syndrome: a randomised clinical trial protocol
Univ Sydney, Australia; Westmead Hosp, Australia; Univ New South Wales, Australia.
Univ Sydney, Australia; Westmead Hosp, Australia; Univ New South Wales, Australia.
Univ Sydney, Australia.
Univ Sydney, Australia; Univ New South Wales, Australia.
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2018 (English)In: BMJ Open, ISSN 2044-6055, E-ISSN 2044-6055, Vol. 8, no 1, article id e019463Article in journal (Refereed) Published
Abstract [en]

Background Identifying simple, low-cost and scalable means of supporting lifestyle change and medication adherence for patients following a cardiovascular (CV) event is important. Objective The TEXTMEDS (TEXT messages to improve MEDiGation adherence and Secondary prevention) study aims to investigate whether a cardiac education and support programme sent via mobile phone text message improves medication adherence and risk factor levels in patients following an acute coronary syndrome (ACS). Study design A single-blind, multicentre, randomised clinical trial of 1400 patients after an ACS with 12 months follow-up. The intervention group will receive multiple weekly text messages that provide information, motivation, support to adhere to medications, quit smoking (if relevant) and recommendations for healthy diet and exercise. The primary endpoint is the percentage of patients who are adherent to cardioprotective medications and the key secondary outcomes are mean systolic blood pressure (BP) and low density lipoprotein cholesterol. Secondary outcomes will also include total cholesterol, mean diastolic BP, the percentage of participants who are adherent to each cardioprotective medication class, the percentage of participants who achieve target levels of CV risk factors, major vascular events, hospital readmissions and all-cause mortality. The study will be augmented by formal economic and proGess evaluations to assess acceptability, utility and Gost-effectiveness. Summary The study will provide multicentre randomised trial evidence of the effects of a text message-based programme on cardioprotective medication adherence and levels of CV risk factors. Ethics and dissemination Primary ethics approval was received from Western Sydney Local Health District Human Research EthiGs Committee (HREC2012/12/4.1 (3648) AU RED HREC/13ANMEAD/15). Results will be disseminated via peer-reviewed publications and presentations at international conferences.

Place, publisher, year, edition, pages
BMJ PUBLISHING GROUP , 2018. Vol. 8, no 1, article id e019463
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General Practice
Identifiers
URN: urn:nbn:se:liu:diva-148155DOI: 10.1136/bmjopen-2017-019463ISI: 000431743500040PubMedID: 29374674OAI: oai:DiVA.org:liu-148155DiVA, id: diva2:1212190
Note

Funding Agencies|National Health and Medical Research Council (NHMRC) [APP1042290]; National Health and Medical Research Council of Australia - Heart Foundation [APP1033478]; Sydney Medical School Foundation Chapman Fellowship; National Health and Medical Research Council [APP1061793]; National Heart Foundation [APP1061793, APP100484]; University of Sydney International Postgraduate Scholarship; University of Sydney Australian Postgraduate Award; NHMRC [1020430]; County Council of Ostergotland international fellowship; Swedish Medical Society

Available from: 2018-06-01 Created: 2018-06-01 Last updated: 2019-05-01

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Rådholm, Karin

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Division of Community MedicineFaculty of Medicine and Health SciencesPrimary Health Care Center Ödeshög
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