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Type I Collagen-Derived Injectable Conductive Hydrogel Scaffolds as Glucose Sensors
Linköping University, Department of Physics, Chemistry and Biology, Molecular Physics. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Physics, Chemistry and Biology, Sensor and Actuator Systems. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Physics, Chemistry and Biology, Sensor and Actuator Systems. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0002-2071-7768
Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Department of Physics, Chemistry and Biology. Linköping University, Faculty of Science & Engineering.
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2018 (English)In: ACS Applied Materials and Interfaces, ISSN 1944-8244, E-ISSN 1944-8252, Vol. 10, no 19, p. 16244-16249Article in journal (Refereed) Published
Abstract [en]

The advent of home blood glucose monitoring revolutionized diabetes management, and the recent introduction of both wearable devices and closed-loop continuous systems has enormously impacted the lives of people with diabetes. We describe the first fully injectable soft electrochemical glucose sensor for in situ monitoring. Collagen, the main component of a native extracellular matrix in humans and animals, was used to fabricate an in situ gellable self-supporting electroconductive hydrogel that can be injected onto an electrode surface or into porcine meat to detect glucose amperometrically. The study provides a proof-of-principle of an injectable electrochemical sensor suitable for monitoring tissue glucose levels that may, with further development, prove clinically useful in the future.

Place, publisher, year, edition, pages
AMER CHEMICAL SOC , 2018. Vol. 10, no 19, p. 16244-16249
Keywords [en]
electroconductive hydrogel; methacrylated collagen; polypyrrole; injectable glucose sensor; diabetes
National Category
Textile, Rubber and Polymeric Materials
Identifiers
URN: urn:nbn:se:liu:diva-148249DOI: 10.1021/acsami.8b04091ISI: 000432753800003PubMedID: 29701457OAI: oai:DiVA.org:liu-148249DiVA, id: diva2:1213393
Note

Funding Agencies|Swedish Research Council [DNR 621-2012-4286, VR-2014-3079, VR 2015-04434 DIABETSENS]; CeNano Ph.D. student salary grant; Carl Tryggers Stifelsen Grant [CTS 16:207]

Available from: 2018-06-04 Created: 2018-06-04 Last updated: 2018-06-25

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