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A novel Schiff base derivative: Synthesis, two-photon absorption properties and application for bioimaging
Wannan Med Coll, Peoples R China.
Anhui Univ, Peoples R China.
Anhui Univ, Peoples R China.
Wannan Med Coll, Peoples R China.
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2018 (English)In: Spectrochimica Acta Part A - Molecular and Biomolecular Spectroscopy, ISSN 1386-1425, E-ISSN 1873-3557, Vol. 198, p. 304-308Article in journal (Refereed) Published
Abstract [en]

A novel donor-pi-acceptor-pi-donor type (D-pi-A-pi-D) Schiff base derivative (L) has been designed and synthesized. The structure of L is confirmed by single-crystal X-ray diffraction analysis as well. The photophysical properties of compound L were comprehensively investigated by using both experimental and theoretical methods. The results indicate that L exhibits large Stokes shift and moderate two-photon action (2PA) cross-section in the near infrared (NIR) region. Furthermore, the confocal microscopy imaging study demonstrates that compound L could penetrate into cells and target the cellular mitochondria compartment. Due to its low cytotoxicity, compound L provides a promising tool for directly lighting up the mitochondria compartment in living HepG2 cells. (C) 2018 Elsevier B.V. All rights reserved.

Place, publisher, year, edition, pages
PERGAMON-ELSEVIER SCIENCE LTD , 2018. Vol. 198, p. 304-308
Keywords [en]
Schiff base derivative; Two-photon absorption; Crystal structure; Bioimaging; Mitochondria
National Category
Inorganic Chemistry
Identifiers
URN: urn:nbn:se:liu:diva-148239DOI: 10.1016/j.saa.2018.03.039ISI: 000432234800037PubMedID: 29558730OAI: oai:DiVA.org:liu-148239DiVA, id: diva2:1213612
Note

Funding Agencies|Natural Science Foundation of Anhui Province [1508085SMB208]; Educational Commission of Anhui Province of China [KJ2016A788]; Swedish Government Strategic Research Area in Materials Science on Functional Materials at Linkoping University (Faculty Grant SFO-Mat-LiU) [2009-00971]

Available from: 2018-06-05 Created: 2018-06-05 Last updated: 2018-06-05

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Uvdal, KajsaHu, Zhang-Jun
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Molecular Surface Physics and Nano ScienceFaculty of Science & Engineering
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