liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Metabolomic profiling of maternal hair suggests rapid development of intrahepatic cholestasis of pregnancy
Univ Auckland, New Zealand.
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Medicine and Health Sciences. Univ Auckland, New Zealand.
Chongqing Med Univ, Peoples R China.
Chongqing Med Univ, Peoples R China.
Show others and affiliations
2018 (English)In: Metabolomics, ISSN 1573-3882, E-ISSN 1573-3890, Vol. 14, no 6, article id 79Article in journal (Refereed) Published
Abstract [en]

Intrahepatic cholestasis of pregnancy (ICP) is a common maternal liver disease; development can result in devastating consequences, including sudden fetal death and stillbirth. Currently, recognition of ICP only occurs following onset of clinical symptoms. Investigate the maternal hair metabolome for predictive biomarkers of ICP. The maternal hair metabolome (gestational age of sampling between 17 and 41 weeks) of 38 Chinese women with ICP and 46 pregnant controls was analysed using gas chromatography-mass spectrometry. Of 105 metabolites detected in hair, none were significantly associated with ICP. Hair samples represent accumulative environmental exposure over time. Samples collected at the onset of ICP did not reveal any metabolic shifts, suggesting rapid development of the disease.

Place, publisher, year, edition, pages
SPRINGER , 2018. Vol. 14, no 6, article id 79
Keywords [en]
Intrahepatic cholestasis of pregnancy; Metabolomics; Hair; Gas chromatography-mass spectrometry
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:liu:diva-148646DOI: 10.1007/s11306-018-1371-7ISI: 000433278000002OAI: oai:DiVA.org:liu-148646DiVA, id: diva2:1219996
Note

Funding Agencies|GRAVIDA: the National Centre for Growth and Development (New Zealand)

Available from: 2018-06-18 Created: 2018-06-18 Last updated: 2018-06-18

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full text

Search in DiVA

By author/editor
Tu, Stephanie
By organisation
Department of Clinical and Experimental MedicineFaculty of Medicine and Health Sciences
In the same journal
Metabolomics
Endocrinology and Diabetes

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 125 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf