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Somatostatin Receptor Expression in Renal Cell Carcinoma-A New Front in the Diagnostics and Treatment of Renal Cell Carcinoma
Linköping University, Department of Clinical and Experimental Medicine, Divison of Neurobiology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Clinical pathology. Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden.
Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden.
Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden.
Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden.
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2018 (English)In: Clinical Genitourinary Cancer, ISSN 1558-7673, E-ISSN 1938-0682, Vol. 16, no 3, p. E517-E520Article in journal (Refereed) Published
Abstract [en]

Clinical Practice Points

Renal cell carcinoma (RCC) has a poor prognosis and is difficult to treat because of its ability to spread asymptomatically and its resistance to chemotherapy.

In this patient series, we report that RCC metastases can be identified using gallium-68 (68Ga)-edotreotide (DOTATOC) positron emission tomography/computed tomography (PET/CT).

Immunostaining of tumor tissue from primary RCC tumors and their matched adrenal, pancreatic, and thyroid metastases showed that RCC cells express membranous somatostatin receptor 2.

These findings indicate that 68Ga-DOTATOC PET/CT can be used as a new imaging modality in management of metastatic RCC and might contribute to the development of new somatostatin analogue-based methods for the treatment of metastatic RCC.

Place, publisher, year, edition, pages
CIG MEDIA GROUP, LP , 2018. Vol. 16, no 3, p. E517-E520
Keywords [en]
Computed tomography; DOTATOC; Positron emission tomography; RCC; SSTR-2
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-149367DOI: 10.1016/j.clgc.2018.03.011ISI: 000432915400005PubMedID: 29656940OAI: oai:DiVA.org:liu-149367DiVA, id: diva2:1229781
Note

Funding Agencies|Swedish Society of Medicine

Available from: 2018-07-02 Created: 2018-07-02 Last updated: 2019-01-07

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