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Variation in pain related to systemic lupus erythematosus (SLE): a 7-year follow-up study
Karolinska Inst, Sweden.
Karolinska Inst, Sweden.
Univ Gothenburg, Sweden; Spenshult Res and Dev Ctr, Sweden; Lund Univ, Sweden.
Karolinska Inst, Sweden.
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2018 (English)In: Clinical Rheumatology, ISSN 0770-3198, E-ISSN 1434-9949, Vol. 37, no 7, p. 1825-1834Article in journal (Refereed) Published
Abstract [en]

We have previously shown that most patients with systemic lupus erythematosus (SLE) reported low degree of SLE-related pain. However, 24% of the patients reported high degree of SLE-related pain, more fatigue, anxiety and depression, and worse health-related quality of life (HRQoL). To explore SLE-related pain, the presence of long-standing widespread pain, and patient-reported outcomes (PROs) after 7 years. Sixty-four out of 84 patients participated in a 7-year follow-up of the original survey and completed the same questionnaires answered at inclusion: pain (VAS 100 mm), fatigue (MAF), HRQoL (SF-36), anxiety and depression (HADS), and, if appropriate, a pain-drawing. Differences between inclusion and follow-up (change) were calculated. The patients with a low degree of SLE-related pain at inclusion reported no changes at follow-up in pain and PROs except for worsening in physical function in SF-36, median change (IQR) 0 (- 10 to 5), p = 0.024. Half of the patients with high degree of pain at inclusion reported decreased pain at follow-up, median change (IQR) 45 (35 to 65), p = 0.021; fatigue, 8 (8 to 17), p = 0.018; anxiety, 4 (1 to 4), p = 0.035; and depression, 4 (2 to 5), p = 0.018 and improvements in most dimensions of SF-36. The remaining half of the patients reported no changes regarding pain and PROs except for a worsening in vitality in SF-36, 20 (15 to 35), p = 0.0018. All patients with remaining high level of pain indicated long-standing widespread pain. After 7 years, a subgroup of patients with SLE reported remaining high level of SLE-related pain and a high symptom burden, including long-standing widespread pain. Such patients require more observant attention to receive appropriate treatment.

Place, publisher, year, edition, pages
SPRINGER LONDON LTD , 2018. Vol. 37, no 7, p. 1825-1834
Keywords [en]
Anxiety; Depression; Fatigue; Health-related quality of life; Pain; SLE
National Category
Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:liu:diva-149528DOI: 10.1007/s10067-018-4079-1ISI: 000435599200011PubMedID: 29654486OAI: oai:DiVA.org:liu-149528DiVA, id: diva2:1231070
Note

Funding Agencies|Swedish Rheumatism Association; King Gustav V 80 Years Foundation; Stockholm County Council; Karolinska Institutet; Linkopings University; Swedish Society of Nursing

Available from: 2018-07-05 Created: 2018-07-05 Last updated: 2019-08-23

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Welin, Elisabet
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Division of Nursing ScienceFaculty of Medicine and Health SciencesDepartment of Rheumatology
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