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Direct Electrical Neurostimulation with Organic Pigment Photocapacitors
Tel Aviv Univ, Israel; Tel Aviv Univ, Israel.
Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering.
Tel Aviv Univ, Israel; Tel Aviv Univ, Israel.
Hebrew Univ Jerusalem, Israel.
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2018 (English)In: Advanced Materials, ISSN 0935-9648, E-ISSN 1521-4095, Vol. 30, no 25, article id 1707292Article in journal (Refereed) Published
Abstract [en]

An efficient nanoscale semiconducting optoelectronic system is reported, which is optimized for neuronal stimulation: the organic electrolytic photocapacitor. The devices comprise a thin (80 nm) trilayer of metal and p-n semiconducting organic nanocrystals. When illuminated in physiological solution, these metal-semiconductor devices charge up, transducing light pulses into localized displacement currents that are strong enough to electrically stimulate neurons with safe light intensities. The devices are freestanding, requiring no wiring or external bias, and are stable in physiological conditions. The semiconductor layers are made using ubiquitous and nontoxic commercial pigments via simple and scalable deposition techniques. It is described how, in physiological media, photovoltage and charging behavior depend on device geometry. To test cell viability and capability of neural stimulation, photostimulation of primary neurons cultured for three weeks on photocapacitor films is shown. Finally, the efficacy of the device is demonstrated by achieving direct optoelectronic stimulation of light-insensitive retinas, proving the potential of this device platform for retinal implant technologies and for stimulation of electrogenic tissues in general. These results substantiate the conclusion that these devices are the first non-Si optoelectronic platform capable of sufficiently large photovoltages and displacement currents to enable true capacitive stimulation of excitable cells.

Place, publisher, year, edition, pages
WILEY-V C H VERLAG GMBH , 2018. Vol. 30, no 25, article id 1707292
Keywords [en]
artificial retina; bioelectronics; neurostimulation; organic semiconductors
National Category
Condensed Matter Physics
Identifiers
URN: urn:nbn:se:liu:diva-149473DOI: 10.1002/adma.201707292ISI: 000435258600011PubMedID: 29717514OAI: oai:DiVA.org:liu-149473DiVA, id: diva2:1231080
Note

Funding Agencies|Knut and Alice Wallenberg Foundation within the framework of the Wallenberg Centre for Molecular Medicine at Linkoping University; Austrian Science Fund FWF via the Wittgenstein Prize Solare Energie Umwandlung [Z222-N19]; European Research Council under the European Community [FUNMANIA-306707]

Available from: 2018-07-05 Created: 2018-07-05 Last updated: 2018-10-05

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