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Normal tissue sparing potential of scanned proton beams with and without respiratory gating for the treatment of internal mammary nodes in breast cancer radiotherapy
The Skandion Clinic, Uppsala, Sweden.ORCID iD: 0000-0001-8171-2541
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Oncology. The Skandion Clinic, Uppsala, Sweden.ORCID iD: 0000-0001-8425-8110
Medical Radiation Physics, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
The Skandion Clinic, Uppsala, Sweden.ORCID iD: 0000-0002-7400-3234
2018 (English)In: Physica medica (Testo stampato), ISSN 1120-1797, E-ISSN 1724-191X, Vol. 52, p. 81-85Article in journal (Refereed) Published
Abstract [en]

Proton therapy has shown potential for reducing doses to normal tissues in breast cancer radiotherapy. However data on the impact of protons when including internal mammary nodes (IMN) in the target for breast radiotherapy is comparatively scarce. This study aimed to evaluate normal tissue doses when including the IMN in regional RT with scanned proton beams, with and without respiratory gating. The study cohort was composed of ten left-sided breast patients CT-scanned during enhanced inspiration gating (EIG) and free-breathing (FB). Proton plans were designed for the target including or excluding the IMN. Targets and organs-at-risk were delineated according to RTOG guidelines. Comparison was performed between dosimetric parameters characterizing target coverage and OAR radiation burden. Statistical significance of differences was tested using a paired, two-tailed Student’s t-test. Inclusion of the IMN in the target volume led to a small increase of the cardiopulmonary burden. The largest differences were seen for the ipsilateral lung where the mean dose increased from 6.1 to 6.6 Gy (RBE) (P < 0.0001) in FB plans and from 6.9 to 7.4 Gy (RBE) (P = 0.003) in EIG plans. Target coverage parameters were very little affected by the inclusion of IMN into the treatment target. Radiotherapy with scanned proton beams has the potential of maintaining low cardiovascular burden when including the IMN into the target, irrespective of whether respiratory gating is used or not.

Place, publisher, year, edition, pages
Elsevier, 2018. Vol. 52, p. 81-85
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Cancer and Oncology
Identifiers
URN: urn:nbn:se:liu:diva-149606DOI: 10.1016/j.ejmp.2018.06.639ISI: 000442110000011PubMedID: 30139613OAI: oai:DiVA.org:liu-149606DiVA, id: diva2:1231896
Available from: 2018-07-09 Created: 2018-07-09 Last updated: 2018-09-03

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Flejmer, Anna M.

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Dasu, AlexandruFlejmer, Anna M.Witt Nyström, Petra
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Division of Surgery, Orthopedics and OncologyFaculty of Medicine and Health SciencesDepartment of Oncology
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