liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
UHRF2 promotes DNA damage response by decreasing p21 via RING finger domain
Chongqing Med Univ, Peoples R China.
Chongqing Med Univ, Peoples R China.
Linköping University, Department of Physics, Chemistry and Biology, Sensor and Actuator Systems. Linköping University, Faculty of Science & Engineering.
Chongqing Med Univ, Peoples R China.
Show others and affiliations
2018 (English)In: Biotechnology letters, ISSN 0141-5492, E-ISSN 1573-6776, Vol. 40, no 8, p. 1181-1188Article in journal (Refereed) Published
Abstract [en]

To investigate the interaction of E3 ubiquitin ligase UHRF2 with p21 and the mechanism of UHRF2 in repairing DNA damage caused by hydroxyurea (HU) in HEK293 cells. Western blotting indicated that the overexpression of UHRF2 reduced the level of p21, particularly in HEK293 cells. Immunoprecipitation and immunofluorescence staining reveled that UHRF2 combined with p21 in the nucleus. In addition, UHRF2 degraded p21 through ubiquitination and shortened the half-life of p21. UHRF2 could repair DNA damage caused by HU treatment, which was impaired by the inhibition of p21 in HEK293 cells. UHRF2 may negatively modulate p21 to regulate DNA damage response, suggesting a novel pathway of UHRF2 repairing DNA damage through the partial regulation of p21.

Place, publisher, year, edition, pages
SPRINGER , 2018. Vol. 40, no 8, p. 1181-1188
Keywords [en]
Degradation; DNA damage response; P21; Ubiquitination; UHRF2
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:liu:diva-149835DOI: 10.1007/s10529-018-2577-5ISI: 000438090800003PubMedID: 29923055OAI: oai:DiVA.org:liu-149835DiVA, id: diva2:1236462
Note

Funding Agencies|National Natural Science Foundation of China [81772178]

Available from: 2018-08-02 Created: 2018-08-02 Last updated: 2018-08-02

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Zeng, Shengyuan
By organisation
Sensor and Actuator SystemsFaculty of Science & Engineering
In the same journal
Biotechnology letters
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 36 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf