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Rotavirus and norovirus in children with severe diarrhea in Burkina Faso before rotavirus vaccine introduction
Univ Ouaga, Burkina Faso; Natl Publ Hlth Lab, Burkina Faso.
Univ Ouaga, Burkina Faso.
Univ Ouaga, Burkina Faso; Charles de Gaulle Pediat Univ Hosp, Burkina Faso.
Natl Publ Hlth Lab, Burkina Faso.
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2018 (English)In: Journal of Medical Virology, ISSN 0146-6615, E-ISSN 1096-9071, Vol. 90, no 9, p. 1453-1460Article in journal (Refereed) Published
Abstract [en]

Burkina Faso introduced rotavirus vaccine (RotaTeq) to the national immunization program in November 2013. This study describes the detection rates, clinical profiles, and molecular epidemiology of rotavirus and norovirus (NoV) infections among children amp;lt;5 years hospitalized (n=154) because of acute diarrhea in Ouagadougou, Burkina Faso, from December 2012 to November 2013, just before the start of vaccination. Overall, 44% and 23% of fecal samples were positive for rotavirus and NoV, respectively, most of them detected during the cold dry season (December-March). The predominant G/P combinations were G12P[8] (47%) and G6P[6] (30%). G2P[4] (n=3), G12P[6] (n=3), and G6P[8] (n=1) werealso detected. Nearly all (94%) successfully genotyped NoV strains belonged to genotype GII.4. The predominance of rotavirus and NoV was noteworthy in the age group 6 months, with 67% rotavirus and 22% NoV, respectively. Vomiting was significantly more common among rotavirus-infected children. To conclude, this study shows high detection rates of both rotavirus and NoV in children with severe diarrhea in Burkina Faso just before the introduction of rotavirus group A vaccination. The results can be used for estimating the impact of rotavirus group A vaccination, which started in the end of 2013. Furthermore, this study shows that the G6P[6] rotavirus strains emerging in Burkina Faso in 2010 is now established as a regionally important genotype.

Place, publisher, year, edition, pages
WILEY , 2018. Vol. 90, no 9, p. 1453-1460
Keywords [en]
Burkina Faso; gastroenteritis; molecular epidemiology; norovirus (NoV); rotavirus
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:liu:diva-149829DOI: 10.1002/jmv.25213ISI: 000438347900005PubMedID: 29718582OAI: oai:DiVA.org:liu-149829DiVA, id: diva2:1236465
Note

Funding Agencies|Swedish Research Council [VR-SRL2013-6727, 320301]; Diarrhoel Disease Center, Linkoping University, Sweden

Available from: 2018-08-02 Created: 2018-08-02 Last updated: 2018-08-02

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