Prevalence of the apolipoprotein E epsilon 4 allele in amyloid beta positive subjects across the spectrum of Alzheimers disease

Mattsson, Niklas; Groot, Colin; Jansen, Willemijn J.; Landau, Susan M.; Villemagne, Victor L.; Engelborghs, Sebastiaan; Mintun, Mark M.; Lleo, Alberto; Molinuevo, Jose Luis; Jagust, William J.; Frisoni, Giovanni B.; Ivanoiu, Adrian; Chetelat, Gael; de Oliveira, Catarina Resende; Rodrigue, Karen M.; Kornhuber, Johannes; Wallin, Anders; Klimkowicz-Mrowiec, Aleksandra; Kandimalla, Ramesh; Popp, Julius; Aalten, Pauline P.; Aarsland, Dag; Alcolea, Daniel; Almdahl, Ina S.; Baldeiras, Ines; van Buchem, Mark A.; Cavedo, Enrica; Chen, Kewei; Cohen, Ann D.; Foerster, Stefan; Fortea, Juan; Frederiksen, Kristian S.; Freund-Levi, Yvonne; Gill, Kiran Dip; Gkatzima, Olymbia; Grimmer, Timo; Hampel, Harald; Herukka, Sanna-Kaisa; Johannsen, Peter; van Laere, Koen; de Leon, Mony J.; Maier, Wolfgang; Marcusson, Jan; Meulenbroek, Olga; Mollergard, Hanne M.; Morris, John C.; Mroczko, Barbara; Nordlund, Arto; Prabhakar, Sudesh; Peters, Oliver; Rami, Lorena; Rodriguez-Rodriguez, Eloy; Roe, Catherine M.; Ruther, Eckart; Santana, Isabel; Schroder, Johannes; Seo, Sang W.; Soininen, Hilkka; Spiru, Luiza; Stomrud, Erik; Struyfs, Hanne; Teunissen, Charlotte E.; Verhey, Frans R. J.; Vos, Stephanie J. B.; van Doorn, Linda J. C. van Waalwijk; Waldemar, Gunhild; Wallin, Asa K.; Wiltfang, Jens; Vandenberghe, Rik; Brooks, David J.; Fladby, Tormod; Rowe, Christopher C.; Drzezga, Alexander; Verbeek, Marcel M.; Sarazin, Marie; Wolk, David A.; Fleisher, Adam S.; Klunk, William E.; Na, Duk L.; Sanchez-Juan, Pascual; Lee, Dong Young; Nordberg, Agneta; Tsolaki, Magda; Camus, Vincent; Rinne, Juha O.; Fagan, Anne M.; Zetterberg, Henrik; Blennow, Kaj; Rabinovici, Gil D.; Hansson, Oskar; van Berckel, Bart N. M.; van der Flier, Wiesje M.; Scheltens, Philip; Visser, Pieter Jelle; Ossenkoppele, Rik

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Prevalence of the apolipoprotein E epsilon 4 allele in amyloid beta positive subjects across the spectrum of Alzheimers disease

Mattsson, Niklas

Lund Univ, Sweden.

Groot, Colin

Vrije Univ Amsterdam, Netherlands; Vrije Univ Amsterdam, Netherlands.

Jansen, Willemijn J.

Maastricht Univ, Netherlands.

Landau, Susan M.

Univ Calif Berkeley, CA 94720 USA.

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2018 (English)In: Alzheimer's & Dementia: Journal of the Alzheimer's Association, ISSN 1552-5260, E-ISSN 1552-5279, Vol. 14, no 7, p. 913-924Article in journal (Refereed) Published

Abstract [en]

Introduction: Apolipoprotein E (APOE) epsilon 4 is the major genetic risk factor for Alzheimers disease (AD), but its prevalence is unclear because earlier studies did not require biomarker evidence of amyloid beta(A beta) pathology. Methods: We included 3451 A beta+ subjects (853 AD-type dementia, 1810 mild cognitive impairment, and 788 cognitively normal). Generalized estimating equation models were used to assess APOE epsilon 4 prevalence in relation to age, sex, education, and geographical location. Results: The APOE epsilon 4 prevalence was 66% in AD-type dementia, 64% in mild cognitive impairment, and 51% in cognitively normal, and it decreased with advancing age in A beta+ cognitively normal and A beta+ mild cognitive impairment (P amp;lt;.05) but not in A beta+ AD dementia (P =.66). The prevalence was highest in Northern Europe but did not vary by sex or education. Discussion: The APOE E4 prevalence in AD was higher than that in previous studies, which did not require presence of A beta pathology. Furthermore, our results highlight disease heterogeneity related to age and geographical location. (C) 2018 the Alzheimers Association. Published by Elsevier Inc. All rights reserved.

Place, publisher, year, edition, pages

ELSEVIER SCIENCE INC , 2018. Vol. 14, no 7, p. 913-924

Keywords [en]

APOE; Prevalence; Amyloid; PET; CSF; Alzheimers disease; Mild cognitive impairment; Subjective cognitive decline; Age; Sex; Education; Geographical location

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Geriatrics

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URN: urn:nbn:se:liu:diva-150288DOI: 10.1016/j.jalz.2018.02.009ISI: 000438783200009PubMedID: 29601787OAI: oai:DiVA.org:liu-150288DiVA, id: diva2:1239663

Note

Funding Agencies|AXA Research Fund; Fondation Universite Pierre et Marie Curie; "Fondation pour la Recherche sur Alzheimer", Paris, France; program "Investissements davenir" [ANR-10-IAIHU-06]; National Institutes of Health [P50 AG005133, RF1 AG025516, PO1 AG025204]; Marie Curie FP7 International Outgoing Fellowship [628812]; Instituto de Salud Carlos III (Fondo de InvestigaciOn Sanitario) [PI08/0139, PI12/02288, PI16/01652]; NIH/NIA [RF1 AG057570, AG035137, AG032554, AG022374, AG13616, AG12101, AG08051, NIH-HLB HL111724]; Instituto de Salud Carlos III (CIBERNED program)

Available from: 2018-08-17 Created: 2018-08-17 Last updated: 2023-03-28

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