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Neuroimaging in the Kleine-Levin Syndrome
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Medicine and Health Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV).ORCID iD: 0000-0002-2167-2450
Department of Neuroscience, Section of Neurosurgery, Uppsala University, Uppsala, Sweden.
Linköping University, Center for Medical Image Science and Visualization (CMIV). Region Östergötland, Local Health Care Services in Central Östergötland, Department of Neurology. Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Department of Neuroscience, Section of Neurology, Uppsala University, Uppsala, Sweden.
2018 (English)In: Current Neurology and Neuroscience Reports, ISSN 1528-4042, E-ISSN 1534-6293, Vol. 18, no 9, article id 58Article, review/survey (Refereed) Published
Abstract [en]

The purpose was to review the most recent literature on neuroimaging in the Kleine-Levin syndrome (KLS). We aimed to investigate if frontotemporal and thalamic dysfunction are key KLS signatures, and if recent research indicates other brain networks of interest that elucidate KLS symptomatology and aetiology. In a comprehensive literature search, we found 12 original articles published 2013-2018. Most studies report deviations related to cerebral perfusion, glucose metabolism, or blood-oxygen-level-dependent responses in frontotemporal areas and/or the thalamus. Studies also report dysfunction in the temporoparietal junction and the oculomotor network that also were related to clinical parameters. We discuss these findings based on recent research on thalamocortical networks and brain stem white matter tracts. The hypothesis of frontotemporal and thalamic involvement in KLS was confirmed, and additional findings in the temporoparietal junction and the oculomotor system suggest a broader network involvement, which can be investigated by future high-resolution and multimodal imaging.

Place, publisher, year, edition, pages
Philadelphia, United States: Springer Healthcare , 2018. Vol. 18, no 9, article id 58
Keywords [en]
Kleine-Levin syndrome (KLS); Functional magnetic resonance imaging (fMRI); Positron emission tomography (PET); Single photon emission computed tomography (SPECT); Magnetic resonance spectroscopy (MRS); Diffusion weighted imaging (DWI)
National Category
Anesthesiology and Intensive Care
Identifiers
URN: urn:nbn:se:liu:diva-150209DOI: 10.1007/s11910-018-0866-yISI: 000439871400001PubMedID: 30030664Scopus ID: 2-s2.0-85050373916OAI: oai:DiVA.org:liu-150209DiVA, id: diva2:1241065
Available from: 2018-08-22 Created: 2018-08-22 Last updated: 2019-05-03Bibliographically approved

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Engström, MariaLandtblom, Anne-Marie
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Division of Radiological SciencesFaculty of Medicine and Health SciencesCenter for Medical Image Science and Visualization (CMIV)Department of NeurologyDivision of Neuro and Inflammation Science
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