liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Exploring the major cross-talking edges of competitive endogenous RNA networks in human Chronic and Acute Myeloid Leukemia
Bose Inst, India.
Saha Inst Nucl Phys, India.
Bose Inst, India.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
Show others and affiliations
2018 (English)In: Biochimica et Biophysica Acta - General Subjects, ISSN 0304-4165, E-ISSN 1872-8006, Vol. 1862, no 9, p. 1883-1892Article in journal (Refereed) Published
Abstract [en]

Background: Human Chronic and Acute Myeloid Leukemia are myeloproliferative disorders in myeloid lineage of blood cells characterized by accumulation of aberrant white blood cells. In cancer, the anomalous transcriptome includes deregulated expression of non-coding RNAs in conjunction with protein-coding mRNAs in human genome. The coding or non-coding RNA transcripts harboring miRNA-binding sites can converse with and regulate each other by explicitly contending for a limited pool of shared miRNAs and act as competitive endogenous RNAs (ceRNAs). An unifying hypothesis attributing modulation of expression of transcripts in this fashion had been defined as competitive endogenous RNA hypothesis. Network built with ceRNAs evidently offers a platform to elucidate complex regulatory interactions at post-transcriptional level in human cancers. Methods: Contemplating cancers of human myeloid lineage we constructed ceRNA networks for CML and AML coding and non-coding repertoire utilizing patient sample data. Through functional enrichment analysis we selected the significant functional modules for transcripts being differentially expressed in Blastic phases of each cancer types with respect to Normal. After retrieving free energy of binding and duplex formation of shared miRNAs on ceRNAs, we performed statistical averaging of energy values over the ensemble of populations considering cellular system as in canonical (Iso-thermal) situation. Results and conclusions: We aimed to shed light on Sibling Rivalry in ceRNA partners from the perspective of statistical thermodynamics, identified major cross-talking tracks and ceRNAs influencing transcripts concerned in myeloid cancer systems. General significance: Insights into ceRNA-regulation will shed light on progression and prognosis of human Chronic and Acute Myeloid Leukemia.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE BV , 2018. Vol. 1862, no 9, p. 1883-1892
Keywords [en]
microRNA; Functional enrichment; microRNA sponging effect; Statistical thermodynamics; miRNA:mRNA binding energy; Competitive binding
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:liu:diva-150206DOI: 10.1016/j.bbagen.2018.06.002ISI: 000440389800005PubMedID: 29902552OAI: oai:DiVA.org:liu-150206DiVA, id: diva2:1241081
Note

Funding Agencies|Science and Engineering Research Board, Department of Science and Technology, Govt. of India [YSS/2015/000115]

Available from: 2018-08-22 Created: 2018-08-22 Last updated: 2018-09-18

Open Access in DiVA

Figures(1180 kB)58 downloads
File information
File name ATTACHMENT02.pdfFile size 1180 kBChecksum SHA-512
1313d0bc50cdff79f6dae50fa17d45de290121c372f01f7a7287c7cd8c708e4d65c9d29cb118440ef646b216b93349aa9e417a8ca307702e417d60b0503d135e
Type attachmentMimetype application/pdf
Supplementary figures and tables(1555 kB)44 downloads
File information
File name ATTACHMENT03.pdfFile size 1555 kBChecksum SHA-512
4fae9e86634f9d13972eabff9a52351c93fc629ebc3d53981b75530fdaceb80c5f7aacd5bd92434bb63ae5b251e4266b410f773960796227c0b185048ea8fabd
Type attachmentMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Das, Jyotirmoy
By organisation
Division of Microbiology and Molecular MedicineFaculty of Medicine and Health Sciences
In the same journal
Biochimica et Biophysica Acta - General Subjects
Biochemistry and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 90 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf