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Flexible wireless powered drug delivery system for targeted administration on cerebral cortex
Korea Adv Inst Sci and Technol, South Korea.
Korea Adv Inst Sci and Technol, South Korea.
Korea Adv Inst Sci and Technol, South Korea.
Korea Adv Inst Sci and Technol, South Korea.
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2018 (English)In: Nano Energy, ISSN 2211-2855, E-ISSN 2211-3282, Vol. 51, p. 102-112Article in journal (Refereed) Published
Abstract [en]

The controlled drug delivery devices helps timely drug administrations and maintenance of effective dose to maximize curing effects with minimal side effects. Application of this technology to various body parts has been limited, especially in organs with curved surface, such as the brain and the eye. Herein, we report a flexible drug delivery microdevice (f-DDM) for controlled administration on the curved organ surface. The unique structure of the f-DDM consists of freestanding gold membranes over the multireservoir array was implemented by reversing the typical fabrication order of the reservoir and sealing membrane. We optimized the design of the f-DDM by a finite element analysis to prevent thermal damage during the laser transfer and the applying current density for reliable drug release through an electrochemical analysis. The wireless power transfer system was applied to f-DDM, which shows stable wirelessly powered operation. The f-DDM was flexible enough to be implantable on the curved cerebral cortex and successfully adopted for delivery of two different chemicals or prevention of seizure activity using an anti-epileptic drug. Our study opens a new avenue for the controlled, region-specific, and combinatorial application of drugs, the key factors for precision medicine.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE BV , 2018. Vol. 51, p. 102-112
Keywords [en]
Drug delivery; Flexible device; Implantable device; Wireless power transfer
National Category
Energy Engineering
Identifiers
URN: urn:nbn:se:liu:diva-150203DOI: 10.1016/j.nanoen.2018.06.015ISI: 000440682100012OAI: oai:DiVA.org:liu-150203DiVA, id: diva2:1241087
Note

Funding Agencies|National Research Foundation (NRF) of Korea - Korea government (MSIP) [NRF-2014R1A2A1A12067558]; Wearable Platform Materials Technology Center (WMC) - National Research Foundation of Korea (NRF) Grant of the Korean Government (MSIP) [2016R1A5A1009926]; National Research Foundation (NRF) of Korea - Ministry of Science, ICT & Future Planning [NRF-2016R1A2B3015167]

Available from: 2018-08-22 Created: 2018-08-22 Last updated: 2018-08-22

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CiteExportLink to record
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Citation style
  • apa
  • harvard1
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Language
  • de-DE
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Output format
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