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Preparation of functionalized protein materials assisted by mechanochemistry
Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics. Linköping University, Faculty of Science & Engineering.
2018 (English)In: Journal of Materials Science, ISSN 0022-2461, E-ISSN 1573-4803, Vol. 53, no 19, p. 13719-13732Article in journal (Refereed) Published
Abstract [en]

Herein, we investigate the suitability of hen egg-white lysozyme (HEWL) as a protein matrix for dispersal of various hydrophobic dyes. Moreover, we investigate the use of a mixer mill for grinding operation as an alternative to hand grinding by mortar and pestle. HEWL and various dyes are mixed by mechanochemistry, and the resulting composite material is dissolved in aqueous acid. The samples are then exposed to conditions promoting self-assembly of HEWL into protein nanofibrils (PNFs). The effect of PNF formation on dye photophysics is investigated by spectroscopic examination by absorption and luminescence spectroscopy, and product morphology is examined by scanning electron microscopy. The self-assembly process results in protein nanofibrils functionalized with luminescent dyes. Such structures may find future applications in various devices for light emission. In addition, we demonstrate that the anticancer drug camptothecin can be incorporated into protein nanofibrils giving materials that can find application as drug delivery agents.

Place, publisher, year, edition, pages
SPRINGER , 2018. Vol. 53, no 19, p. 13719-13732
National Category
Polymer Chemistry
Identifiers
URN: urn:nbn:se:liu:diva-150199DOI: 10.1007/s10853-018-2461-7ISI: 000440047900036OAI: oai:DiVA.org:liu-150199DiVA, id: diva2:1241097
Note

Funding Agencies|China Scholarship Council; Swedish Government Strategic Research Area in Materials Science on Functional Materials at Linkoping University [2009-00971]

Available from: 2018-08-22 Created: 2018-08-22 Last updated: 2018-09-11

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