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DNA methylation as a genomic marker of exposure to chemical and environmental agents
Univ Edinburgh, Scotland.
Univ Edinburgh, Scotland.
Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences.ORCID iD: 0000-0003-1239-5495
Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences.
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2018 (English)In: Current opinion in chemical biology, ISSN 1367-5931, E-ISSN 1879-0402, Vol. 45, p. 48-56Article, review/survey (Refereed) Published
Abstract [en]

Recent progress in interpreting comprehensive genetic and epigenetic profiles for human cellular states has contributed new insights into the developmental origins of disease, elucidated novel signalling pathways and enhanced drug discovery programs. A similar comprehensive approach to decoding the epigenetic readouts from chemical challenges in vivo would yield new paradigms for monitoring and assessing environmental exposure in model systems and humans.

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ELSEVIER SCI LTD , 2018. Vol. 45, p. 48-56
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Biochemistry and Molecular Biology
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URN: urn:nbn:se:liu:diva-150871DOI: 10.1016/j.cbpa.2018.02.006ISI: 000441686700008PubMedID: 29505975OAI: oai:DiVA.org:liu-150871DiVA, id: diva2:1245891
Note

Funding Agencies|LRI grant from CEFIC; Medical Research Council [MC_PC_U127574433]; Swedish Research Council; Swedish Cancer Society; BBSRC; BHF

Available from: 2018-09-06 Created: 2018-09-06 Last updated: 2018-09-06

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