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Oral microbiome development during childhood: an ecological succession influenced by postnatal factors and associated with tooth decay
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. CSISP FISABIO, Spain; Inst Agrochem and Food Technol IATA CSIC, Spain.
Inst Agrochem and Food Technol IATA CSIC, Spain.
Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center of Paediatrics and Gynaecology and Obstetrics, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus.
CSISP FISABIO, Spain.
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2018 (English)In: The ISME Journal, ISSN 1751-7362, E-ISSN 1751-7370, Vol. 12, no 9, p. 2292-2306Article in journal (Refereed) Published
Abstract [en]

Information on how the oral microbiome develops during early childhood and how external factors influence this ecological process is scarce. We used high-throughput sequencing to characterize bacterial composition in saliva samples collected at 3, 6, 12, 24 months and 7 years of age in 90 longitudinally followed children, for whom clinical, dietary and health data were collected. Bacterial composition patterns changed through time, starting with "early colonizers", including Streptococcus and Veillonella; other bacterial genera such as Neisseria settled after 1 or 2 years of age. Dental caries development was associated with diverging microbial composition through time. Streptococcus cristatus appeared to be associated with increased risk of developing tooth decay and its role as potential biomarker of the disease should be studied with species-specific probes. Infants born by C-section had initially skewed bacterial content compared with vaginally delivered infants, but this was recovered with age. Shorter breastfeeding habits and antibiotic treatment during the first 2 years of age were associated with a distinct bacterial composition at later age. The findings presented describe oral microbiota development as an ecological succession where altered colonization pattern during the first year of life may have long-term consequences for childs oral and systemic health.

Place, publisher, year, edition, pages
NATURE PUBLISHING GROUP , 2018. Vol. 12, no 9, p. 2292-2306
National Category
Microbiology
Identifiers
URN: urn:nbn:se:liu:diva-150853DOI: 10.1038/s41396-018-0204-zISI: 000441581700016PubMedID: 29899505OAI: oai:DiVA.org:liu-150853DiVA, id: diva2:1245912
Note

Funding Agencies|Spanish Ministry of Economy and Competitiveness [BIO2015-68711-R]; Research Council for the South-East Sweden [79001]; Swedish Research Council [2016-01698]; Swedish Heart and Lung Foundation [20140321]; Medical Research Council of Southeast Sweden [FORSS-573471]; Cancer and Allergy Foundation; European Research Council (ERC) [639226]

Available from: 2018-09-06 Created: 2018-09-06 Last updated: 2019-04-18

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Dzidic, MajdaAbrahamsson, ThomasJenmalm, Maria
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Division of Neuro and Inflammation ScienceFaculty of Medicine and Health SciencesDivision of Children's and Women's healthH.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus
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