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Molecular Regulation of Differentiation in Early B-Lymphocyte Development
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Lund Univ, Sweden.
2018 (English)In: International Journal of Molecular Sciences, ISSN 1422-0067, E-ISSN 1422-0067, Vol. 19, no 7, article id 1928Article, review/survey (Refereed) Published
Abstract [en]

B-lymphocyte differentiation is one of the best understood developmental pathways in the hematopoietic system. Our understanding of the developmental trajectories linking the multipotent hematopoietic stem cell to the mature functional B-lymphocyte is extensive as a result of efforts to identify and prospectively isolate progenitors at defined maturation stages. The identification of defined progenitor compartments has been instrumental for the resolution of the molecular features that defines given developmental stages as well as for our understanding of the mechanisms that drive the progressive maturation process. Over the last years it has become increasingly clear that the regulatory networks that control normal B-cell differentiation are targeted by mutations in human B-lineage malignancies. This generates a most interesting link between development and disease that can be explored to improve diagnosis and treatment protocols in lymphoid malignancies. The aim of this review is to provide an overview of our current understanding of molecular regulation in normal and malignant B-cell development.

Place, publisher, year, edition, pages
MDPI , 2018. Vol. 19, no 7, article id 1928
Keywords [en]
B-lymphocyte; development; transcription factors; lymphoid leukemia
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:liu:diva-151213DOI: 10.3390/ijms19071928ISI: 000442807400107PubMedID: 29966360OAI: oai:DiVA.org:liu-151213DiVA, id: diva2:1248028
Note

Funding Agencies|Swedish Cancer Society; Swedish Childhood Cancer Foundation; Swedish Research Council; Stem Therapy program; BioCare program; Knut and Alice Wallenbergs Foundation

Available from: 2018-09-13 Created: 2018-09-13 Last updated: 2018-10-15

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Citation style
  • apa
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Language
  • de-DE
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Output format
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