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A 3-year longitudinal study of skeletal effects and growth in children after kidney transplantation
Gothenburg Univ, Sweden.
Gothenburg Univ, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Clinical Chemistry.
2018 (English)In: Pediatric Transplantation, ISSN 1397-3142, E-ISSN 1399-3046, Vol. 22, no 6, article id e13253Article in journal (Refereed) Published
Abstract [en]

This prospective study investigated growth and skeletal development for 3years after kidney transplantation in pediatric patients, 3.4-15.0years of age. Growth, BMD, bone resorption markers (CTX and TRACP5b), bone formation markers (PINP, ALP, and osteocalcin), PTH, and vitamin D were assessed at start, 3, 12, and 36months after transplantation. Median GFR was 63 (range 37-96) mL/min/1.73m(2) after 3years. The median height SDS increased from -1.7 to -1.1, and median BMI SDS increased from -0.1 to 0.6 over 3years, which shows that transplantation had a favorable outcome on growth. Fat mass increased after transplantation at all time points, whereas lean mass increased after 1year and 3years. Total BMC increased at all time points. No changes were observed for total BMD. Bone resorption markers decreased initially after 3months and remained stable throughout the study, whereas the bone formation markers decreased initially, but successively increased over the study period. In conclusion, this study demonstrates that height SDS and BMI SDS increased, along with the increased formation markers that reveal a positive bone acquisition after kidney transplantation, which was reflected by the significant increase in total body BMC.

Place, publisher, year, edition, pages
WILEY , 2018. Vol. 22, no 6, article id e13253
Keywords [en]
body composition; bone markers; bone mineral density; dual-energy X-ray absorptiometry; growth; pediatric kidney transplantation
National Category
Surgery
Identifiers
URN: urn:nbn:se:liu:diva-151195DOI: 10.1111/petr.13253ISI: 000442223700021PubMedID: 29992675OAI: oai:DiVA.org:liu-151195DiVA, id: diva2:1248615
Note

Funding Agencies|Swedish Government; Memorial Foundation Professor Lars-Erik Gelin; ALF; Region Ostergotland, Sweden

Available from: 2018-09-17 Created: 2018-09-17 Last updated: 2018-11-07

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Magnusson, Per

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Division of Microbiology and Molecular MedicineFaculty of Medicine and Health SciencesDepartment of Clinical Chemistry
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