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Biophysics of BK Channel Gating
David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, United States.
David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, United States.
2016 (English)In: International review of neurobiology, ISSN 0074-7742, E-ISSN 2162-5514, Vol. 128, p. 1-49Article, review/survey (Refereed) Published
Abstract [en]

BK channels are universal regulators of cell excitability, given their exceptional unitary conductance selective for K(+), joint activation mechanism by membrane depolarization and intracellular [Ca(2+)] elevation, and broad expression pattern. In this chapter, we discuss the structural basis and operational principles of their activation, or gating, by membrane potential and calcium. We also discuss how the two activation mechanisms interact to culminate in channel opening. As members of the voltage-gated potassium channel superfamily, BK channels are discussed in the context of archetypal family members, in terms of similarities that help us understand their function, but also seminal structural and biophysical differences that confer unique functional properties.

Place, publisher, year, edition, pages
Elsevier, 2016. Vol. 128, p. 1-49
Keywords [en]
Allostery, Calcium signaling, Ion channel, Ligand-dependent activation, MaxiK, VSD, Voltage-dependent activation
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:liu:diva-151620DOI: 10.1016/bs.irn.2016.03.013PubMedID: 27238260OAI: oai:DiVA.org:liu-151620DiVA, id: diva2:1251677
Available from: 2018-09-27 Created: 2018-09-27 Last updated: 2018-11-16

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