liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The Tiny Drosophila Melanogaster for the Biggest Answers in Huntingtons Disease
Univ Nacl Autonoma Mexico, Mexico.
Linköping University, Department of Clinical and Experimental Medicine, Divison of Neurobiology. Linköping University, Faculty of Medicine and Health Sciences.
Univ Santiago Chile, Chile; Univ Bernardo OHiggins, Chile.
Univ Las Amer, Chile.
Show others and affiliations
2018 (English)In: International Journal of Molecular Sciences, ISSN 1422-0067, E-ISSN 1422-0067, Vol. 19, no 8, article id 2398Article, review/survey (Refereed) Published
Abstract [en]

The average life expectancy for humans has increased over the last years. However, the quality of the later stages of life is low and is considered a public health issue of global importance. Late adulthood and the transition into the later stage of life occasionally leads to neurodegenerative diseases that selectively affect different types of neurons and brain regions, producing motor dysfunctions, cognitive impairment, and psychiatric disorders that are progressive, irreversible, without remission periods, and incurable. Huntingtons disease (HD) is a common neurodegenerative disorder. In the 25 years since the mutation of the huntingtin (HTT) gene was identified as the molecule responsible for this neural disorder, a variety of animal models, including the fruit fly, have been used to study the disease. Here, we review recent research that used Drosophila as an experimental tool for improving knowledge about the molecular and cellular mechanisms underpinning HD.

Place, publisher, year, edition, pages
MDPI , 2018. Vol. 19, no 8, article id 2398
Keywords [en]
neurodegenerative diseases; IT15; LOMARS; HTT; HD; huntingtin; mHTT; polyQ; polyglutamine disorders; chorea; neostriatum; fruit fly
National Category
Neurology
Identifiers
URN: urn:nbn:se:liu:diva-151801DOI: 10.3390/ijms19082398ISI: 000442869800250PubMedID: 30110961OAI: oai:DiVA.org:liu-151801DiVA, id: diva2:1253274
Note

Funding Agencies|FONDECYT [1151206]; RING-CONICYT [ACT1401]

Available from: 2018-10-04 Created: 2018-10-04 Last updated: 2019-04-10

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Authority records BETA

Estrada-Mondragon, Argel

Search in DiVA

By author/editor
Estrada-Mondragon, Argel
By organisation
Divison of NeurobiologyFaculty of Medicine and Health Sciences
In the same journal
International Journal of Molecular Sciences
Neurology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 12 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf