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Direct characterization and removal of interfering absorption trends in two-layer turbid media
The Institute of Optics, University of Rochester, Rochester, New York, USA .
The Institute of Optics, University of Rochester, Rochester, New York, USA .
2005 (English)In: Journal of the Optical Society of America A, ISSN 0740-3232, Vol. 22, no 9, p. 1874-882Article in journal (Refereed) Published
Abstract [en]

We propose a method to isolate absorption trends confined to the lower layer of a two-layer turbid medium, as is desired in near-infrared spectroscopy (NIRS) of cerebral hemodynamics. Several two-layer Monte Carlo simulations of NIRS time series were generated using a physiologically relevant range of optical properties and varying the absorption coefficients due to bottom-layer, top-layer, and/or global fluctuations. Initial results showed that by measuring absorption trends at two source–detector separations and performing a least-squares fit of one to the other, processed signals strongly resemble the simulated bottom-layer absorption properties. Through this approach, it was demonstrated that fitting coefficients can be estimated within less than ±2% of the ideal value without any a priori knowledge of the optical properties present in the model. An analytical approximation for the least-squares coefficient provides physical insight into the nature of errors and suggests ways to reduce them.

Place, publisher, year, edition, pages
OSA Publishing , 2005. Vol. 22, no 9, p. 1874-882
National Category
Physical Sciences
Identifiers
URN: urn:nbn:se:liu:diva-152342DOI: 10.1364/josaa.22.001874OAI: oai:DiVA.org:liu-152342DiVA, id: diva2:1259369
Available from: 2018-10-29 Created: 2018-10-29 Last updated: 2018-10-29Bibliographically approved

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Saager, Rolf B.

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